Lucio Freitas Junior
Lucio Freitas Junior
Institute of Biomedical Sciences, ICB, University of São Paulo
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Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum
LH Freitas-Junior, E Bottius, LA Pirrit, KW Deitsch, C Scheidig, F Guinet, ...
Nature 407 (6807), 1018-1022, 2000
Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites
LH Freitas-Junior, R Hernandez-Rivas, SA Ralph, D Montiel-Condado, ...
Cell 121 (1), 25-36, 2005
Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum
MT Duraisingh, TS Voss, AJ Marty, MF Duffy, RT Good, JK Thompson, ...
Cell 121 (1), 13-24, 2005
In vitro and in vivo experimental models for drug screening and development for Chagas disease
AJ Romanha, SL Castro, MNC Soeiro, J Lannes-Vieira, I Ribeiro, ...
Memórias do Instituto Oswaldo Cruz 105, 233-238, 2010
Visceral leishmaniasis treatment: what do we have, what do we need and how to deliver it?
LH Freitas-Junior, E Chatelain, HA Kim, JL Siqueira-Neto
International Journal for Parasitology: Drugs and Drug Resistance 2, 11-19, 2012
The mucin-like glycoprotein super-family of Trypanosoma cruzi: structure and biological roles
A Acosta-Serrano, IC Almeida, LH Freitas-Junior, N Yoshida, ...
Molecular and biochemical parasitology 114 (2), 143-150, 2001
Multitarget drug discovery for tuberculosis and other infectious diseases
K Li, LA Schurig-Briccio, X Feng, A Upadhyay, V Pujari, B Lechartier, ...
Journal of medicinal chemistry 57 (7), 3126-3139, 2014
Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and …
CB Moraes, MA Giardini, H Kim, CH Franco, AM Araujo-Junior, ...
Scientific reports 4 (1), 4703, 2014
An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages
JL Siqueira-Neto, S Moon, J Jang, G Yang, C Lee, HK Moon, E Chatelain, ...
PLoS neglected tropical diseases 6 (6), e1671, 2012
Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds
JL Siqueira-Neto, OR Song, H Oh, JH Sohn, G Yang, J Nam, J Jang, ...
PLoS neglected tropical diseases 4 (5), e675, 2010
A central role for Plasmodium falciparum subtelomeric regions in spatial positioning and telomere length regulation
LM Figueiredo, LH Freitas‐Junior, E Bottius, JC Olivo‐Marin, A Scherf
The EMBO journal, 2002
A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes
RA O'Donnell, LH Freitas‐Junior, PR Preiser, DH Williamson, ...
The EMBO journal, 2002
Plasmodium telomeres: a pathogen's perspective
A Scherf, LM Figueiredo, LH Freitas-Junior
Current opinion in microbiology 4 (4), 409-414, 2001
Biochemical characterization of proline racemases from the human protozoan parasite Trypanosoma cruzi and definition of putative protein signatures
N Chamond, C Grégoire, N Coatnoan, C Rougeot, LH Freitas-Junior, ...
Journal of Biological Chemistry 278 (18), 15484-15494, 2003
UV-C (254 nm) lethal doses for SARS-CoV-2
CP Sabino, FP Sellera, DF Sales-Medina, RRG Machado, EL Durigon, ...
Photodiagnosis and Photodynamic Therapy 32, 101995, 2020
An image analysis algorithm for malaria parasite stage classification and viability quantification
S Moon, S Lee, H Kim, LH Freitas-Junior, M Kang, L Ayong, MAE Hansen
PloS one 8 (4), e61812, 2013
Zika antiviral chemotherapy: identification of drugs and promising starting points for drug discovery from an FDA-approved library
BS Pascoalino, G Courtemanche, MT Cordeiro, LHVG Gil, ...
F1000Research 5, 2016
Identification of novel compounds inhibiting chikungunya virus-induced cell death by high throughput screening of a kinase inhibitor library
DJM Cruz, RM Bonotto, RGB Gomes, CT da Silva, JB Taniguchi, JH No, ...
PLoS neglected tropical diseases 7 (10), e2471, 2013
Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity
JH No, F de Macedo Dossin, Y Zhang, YL Liu, W Zhu, X Feng, JA Yoo, ...
Proceedings of the National Academy of Sciences 109 (11), 4058-4063, 2012
Open drug discovery for the Zika virus
S Ekins, D Mietchen, M Coffee, TP Stratton, JS Freundlich, ...
F1000Research 5, 2016
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