Farren Isaacs
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Programming cells by multiplex genome engineering and accelerated evolution
HH Wang, FJ Isaacs, PA Carr, ZZ Sun, G Xu, CR Forest, GM Church
Nature 460 (7257), 894-898, 2009
Genomically recoded organisms expand biological functions
MJ Lajoie, AJ Rovner, DB Goodman, HR Aerni, AD Haimovich, ...
science 342 (6156), 357-360, 2013
Computational studies of gene regulatory networks: in numero molecular biology
J Hasty, D McMillen, F Isaacs, JJ Collins
Nature Reviews Genetics 2 (4), 268-279, 2001
Phenotypic consequences of promoter-mediated transcriptional noise
WJ Blake, G Balázsi, MA Kohanski, FJ Isaacs, KF Murphy, Y Kuang, ...
Molecular cell 24 (6), 853-865, 2006
Engineered riboregulators enable post-transcriptional control of gene expression
FJ Isaacs, DJ Dwyer, C Ding, DD Pervouchine, CR Cantor, JJ Collins
Nature biotechnology 22 (7), 841-847, 2004
Precise manipulation of chromosomes in vivo enables genome-wide codon replacement
FJ Isaacs, PA Carr, HH Wang, MJ Lajoie, B Sterling, L Kraal, AC Tolonen, ...
Science 333 (6040), 348-353, 2011
Prediction and measurement of an autoregulatory genetic module
FJ Isaacs, J Hasty, CR Cantor, JJ Collins
Proceedings of the National Academy of Sciences 100 (13), 7714-7719, 2003
A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes
L Bazak, A Haviv, M Barak, J Jacob-Hirsch, P Deng, R Zhang, FJ Isaacs, ...
Genome research 24 (3), 365-376, 2014
The real cost of sequencing: scaling computation to keep pace with data generation
P Muir, S Li, S Lou, D Wang, DJ Spakowicz, L Salichos, J Zhang, ...
Genome biology 17, 1-9, 2016
RNA synthetic biology
FJ Isaacs, DJ Dwyer, JJ Collins
Nature biotechnology 24 (5), 545-554, 2006
Recoded organisms engineered to depend on synthetic amino acids
AJ Rovner, AD Haimovich, SR Katz, Z Li, MW Grome, BM Gassaway, ...
Nature 518 (7537), 89-93, 2015
Designer gene networks: Towards fundamental cellular control
J Hasty, F Isaacs, M Dolnik, D McMillen, JJ Collins
Chaos: An Interdisciplinary Journal of Nonlinear Science 11 (1), 207-220, 2001
Engineering an allosteric transcription factor to respond to new ligands
ND Taylor, AS Garruss, R Moretti, S Chan, MA Arbing, D Cascio, ...
Nature methods 13 (2), 177-183, 2016
The genome project-write
JD Boeke, G Church, A Hessel, NJ Kelley, A Arkin, Y Cai, R Carlson, ...
Science 353 (6295), 126-127, 2016
Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids
M Amiram, AD Haimovich, C Fan, YS Wang, HR Aerni, I Ntai, DW Moonan, ...
Nature biotechnology 33 (12), 1272-1279, 2015
Potent noncovalent inhibitors of the main protease of SARS-CoV-2 from molecular sculpting of the drug perampanel guided by free energy perturbation calculations
CH Zhang, EA Stone, M Deshmukh, JA Ippolito, MM Ghahremanpour, ...
ACS central science 7 (3), 467-475, 2021
Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids
RW Martin, BJ Des Soye, YC Kwon, J Kay, RG Davis, PM Thomas, ...
Nature communications 9 (1), 1203, 2018
Tracking, tuning, and terminating microbial physiology using synthetic riboregulators
JM Callura, DJ Dwyer, FJ Isaacs, CR Cantor, JJ Collins
Proceedings of the National Academy of Sciences 107 (36), 15898-15903, 2010
Cell-free Protein Synthesis from a Release Factor 1 Deficient Escherichia coli Activates Efficient and Multiple Site-specific Nonstandard Amino Acid Incorporation
SH Hong, I Ntai, AD Haimovich, NL Kelleher, FJ Isaacs, MC Jewett
ACS synthetic biology 3 (6), 398-409, 2014
Crystal structure of an insect antifreeze protein and its implications for ice binding
A Hakim, JB Nguyen, K Basu, DF Zhu, D Thakral, PL Davies, FJ Isaacs, ...
Journal of Biological Chemistry 288 (17), 12295-12304, 2013
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Articles 1–20