| 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3 A Kultti, S Pasonen-Seppänen, M Jauhiainen, KJ Rilla, R Kärnä, E Pyöriä, ... Experimental cell research 315 (11), 1914-1923, 2009 | 331 | 2009 |
| Hyaluronan enters keratinocytes by a novel endocytic route for catabolism R Tammi, K Rilla, JP Pienimäki, DK MacCallum, M Hogg, M Luukkonen, ... Journal of Biological Chemistry 276 (37), 35111-35122, 2001 | 292 | 2001 |
| Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan JP Pienimäki, K Rilla, C Fülöp, RK Sironen, S Karvinen, S Pasonen, ... Journal of biological chemistry 276 (23), 20428-20435, 2001 | 261 | 2001 |
| Transcriptional and post‐translational regulation of hyaluronan synthesis RH Tammi, AG Passi, K Rilla, E Karousou, D Vigetti, K Makkonen, ... The FEBS journal 278 (9), 1419-1428, 2011 | 253 | 2011 |
| High numbers of macrophages, especially M2‐like (CD 163‐positive), correlate with hyaluronan accumulation and poor outcome in breast cancer S Tiainen, R Tumelius, K Rilla, K Hämäläinen, M Tammi, R Tammi, ... Histopathology 66 (6), 873-883, 2015 | 238 | 2015 |
| The power of imaging to understand extracellular vesicle biology in vivo FJ Verweij, L Balaj, CM Boulanger, DRF Carter, EB Compeer, G D’angelo, ... Nature methods 18 (9), 1013-1026, 2021 | 189 | 2021 |
| Extracellular vesicles are integral and functional components of the extracellular matrix K Rilla, AM Mustonen, UT Arasu, K Härkönen, J Matilainen, P Nieminen Matrix Biology 75, 201-219, 2019 | 182 | 2019 |
| Hyaluronan synthases (HAS1–3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival P Auvinen, K Rilla, R Tumelius, M Tammi, R Sironen, Y Soini, VM Kosma, ... Breast cancer research and treatment 143, 277-286, 2014 | 182 | 2014 |
| Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells J Viiri, M Amadio, N Marchesi, JMT Hyttinen, N Kivinen, R Sironen, K Rilla, ... PloS one 8 (7), e69563, 2013 | 166 | 2013 |
| Hyaluronan synthesis induces microvillus-like cell surface protrusions A Kultti, K Rilla, R Tiihonen, AP Spicer, RH Tammi, MI Tammi Journal of Biological Chemistry 281 (23), 15821-15828, 2006 | 160 | 2006 |
| Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy‐mediated proteolysis in human retinal pigment epithelial cells T Ryhänen, JMT Hyttinen, J Kopitz, K Rilla, E Kuusisto, E Mannermaa, ... Journal of cellular and molecular medicine 13 (9b), 3616-3631, 2009 | 150 | 2009 |
| Pericellular hyaluronan coat visualized in live cells with a fluorescent probe is scaffolded by plasma membrane protrusions K Rilla, R Tiihonen, A Kultti, M Tammi, R Tammi Journal of Histochemistry & Cytochemistry 56 (10), 901-910, 2008 | 137 | 2008 |
| Hyaluronan Synthase 1 (HAS1) Requires Higher Cellular UDP-GlcNAc Concentration than HAS2 and HAS3*[S] K Rilla, S Oikari, TA Jokela, JMT Hyttinen, R Kärnä, RH Tammi, MI Tammi Journal of Biological Chemistry 288 (8), 5973-5983, 2013 | 136 | 2013 |
| Plasma Membrane Residence of Hyaluronan Synthase Is Coupled to Its Enzymatic Activity*[boxs] K Rilla, H Siiskonen, AP Spicer, JMT Hyttinen, MI Tammi, RH Tammi Journal of Biological Chemistry 280 (36), 31890-31897, 2005 | 124 | 2005 |
| Hyaluronan synthase 1: a mysterious enzyme with unexpected functions H Siiskonen, S Oikari, S Pasonen-Seppänen, K Rilla Frontiers in immunology 6, 126938, 2015 | 120 | 2015 |
| Hyaluronan production enhances shedding of plasma membrane-derived microvesicles K Rilla, S Pasonen-Seppänen, AJ Deen, VVT Koistinen, S Wojciechowski, ... Experimental cell research 319 (13), 2006-2018, 2013 | 115 | 2013 |
| Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs J Karttunen, M Heiskanen, V Navarro-Ferrandis, S Das Gupta, ... Journal of extracellular vesicles 8 (1), 1555410, 2019 | 107 | 2019 |
| The hyaluronan synthesis inhibitor 4-methylumbelliferone prevents keratinocyte activation and epidermal hyperproliferation induced by epidermal growth factor K Rilla, S Pasonen-Seppänen, J Rieppo, M Tammi, R Tammi Journal of investigative dermatology 123 (4), 708-714, 2004 | 107 | 2004 |
| Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches JA Welsh, DCI Goberdhan, L O'Driscoll, EI Buzas, C Blenkiron, ... Journal of extracellular vesicles 13 (2), e12404, 2024 | 101 | 2024 |
| Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma TK Nykopp, K Rilla, MI Tammi, RH Tammi, R Sironen, K Hämäläinen, ... BMC cancer 10, 1-9, 2010 | 99 | 2010 |
