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Sumit Basu
Sumit Basu
Senior Principal Scientist,PKS Oncology, Novartis
E-mail confirmado em novartis.com
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First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics
B Wu, K Kulkarni, S Basu, S Zhang, M Hu
Journal of pharmaceutical sciences 100 (9), 3655-3681, 2011
3292011
Regioselective sulfation and glucuronidation of phenolics: insights into the structural basis
B Wu, S Basu, S Meng, X Wang, M Hu
Current drug metabolism 12 (9), 900-916, 2011
1142011
Glucuronidation: Driving Factors and Their Impact on Glucuronide Disposition
G Yang, S Ge, R Singh, S Basu, K Shatzer, M Zen, J Liu, T Tu, C Zhang, ...
Drug Metabolism Reviews 7, 78, 2017
1132017
Development of biodegradable polymer based tamoxifen citrate loaded nanoparticles and effect of some manufacturing process parameters on them: a physicochemical and in-vitro …
B Sahana, K Santra, S Basu, B Mukherjee
International journal of nanomedicine, 621-630, 2010
912010
Bioavailability Challenges Associated with Development of Saponins as Therapeutic and Chemopreventive Agents.
S Gao, S Basu, Z Yang, A Deb, M Hu
Current drug targets, 2013
742013
Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective
AE Riedmaier, K DeMent, J Huckle, P Bransford, C Stillhart, R Lloyd, ...
AAPS 22 (123), 2020
702020
Multi-omics analyses reveal metabolic alterations regulated by hepatitis B virus core protein in hepatocellular carcinoma cells
XP Xie Q, Fan F, Wei W, Liu Y, Xu Z, Zhai L, Qi Y, Ye B, Zhang Y, Basu S ...
Scientific Reports 7, 2017
482017
Development and validation of an UPLC-MS/MS method for the quantification of irinotecan, SN-38 and SN-38 glucuronide in plasma, urine, feces, liver and kidney: Application to a …
S Basu, M Zeng, T Yin, S Gao, M Hu
Journal of Chromatography B 1015, 34-41, 2016
422016
Disposition of Flavonoids via Recycling: Direct Biliary Excretion of Enterically or Extrahepatically Derived Flavonoid Glucuronides
M Zeng, R Sun, S Basu, Y Ma, S Ge, T Yin, S Gao, M Hu
Molecular Nutrition & Food Research, 2016
422016
Colloidal gold-loaded, biodegradable, polymer-based stavudine nanoparticle uptake by macrophages: an in vitro study.
S Basu, B Mukherjee, SR Chowdhury, P Paul
International Journal of Nanomedicine 7, 6049-61, 2012
382012
Oral Bioavailability Challenges of Natural Products Used in Cancer Chemoprevention
S Gao, S Basu, A Deb, M Hu
Progress in Chemistry 25 (9), 2013
312013
Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Pediatric Populations Using PK-Sim
S Basu, YT Lien, V Vozmediano, JF Schlender, T Eissing, ...
Frontiers in Pharmacology 11 (868), 1-13, 2020
302020
Revolving door action of breast cancer resistance protein (BCRP) facilitates or controls the efflux of flavone glucuronides from UGT1A9-overexpressing HeLa cells
Y Wei, B Wu, W Jiang, T Yin, X Jia, S Basu, G Yang, M Hu
Molecular pharmaceutics 10 (5), 1736-1750, 2013
302013
Understanding mechanisms of food effect and developing reliable PBPK models using a middle-out approach
XJH Pepin, JE Huckle, RV Alluri, S Basu, S Dodd, N Parrott, ...
The AAPS Journal 23, 1-14, 2021
272021
Physiologically Based Pharmacokinetic Modeling to Evaluate Formulation Factors Influencing Bioequivalence of Metoprolol Extended‐Release Products
S Basu, H Yang, L Fang, M Gonzalez‐Sales, L Zhao, MN Trame, L Lesko, ...
Journal of Clinical Pharmacology, 1-12, 2019
202019
Ceftolozane/tazobactam probability of target attainment and outcomes in participants with augmented renal clearance from the randomized phase 3 ASPECT-NP trial
AF Shorr, CJ Bruno, Z Zhang, E Jensen, Gao, W, HP Feng, JA Huntington, ...
Critical Care 25 (1), 354, 2021
192021
Xiao-Chai-Hu-Tang (XCHT) Intervening Irinotecan’s Disposition: The Potential of XCHT in Alleviating Irinotecan-Induced Diarrhea
R Sun, S Basu, M Zeng, R Sunsong, L Li, R Ghose, W Wang, Z Liu, M Hu, ...
Current Cancer Drug Targets, 2018
102018
Physiologically‐based pharmacokinetics modeling to investigate formulation factors influencing the generic substitution of dabigatran etexilate
N Farhan, R Cristofoletti, S Basu, S Kim, K Lingineni, S Jiang, JD Brown, ...
CPT: Pharmacometrics & Systems Pharmacology 10 (3), 199-210, 2021
92021
Role of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro
P Mallick, S Basu, B Moorthy, R Ghose
Toxicology in Vitro, 2017
92017
Is there a paradigm shift in use of microsomes and hepatocytes in drug discovery and development?
S Basu, AN Shaik
ADMET and DMPK 4 (2), 114-116, 2016
92016
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