Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation MP Tariq Afroz, Eva-Maria Hock, Patrick Ernst, Chiara Foglieni, Melanie ... Nature Communications 8, 2017 | 270 | 2017 |
Reprogramming Bacteriophage Host Range through Structure-Guided Design of Chimeric Receptor Binding Proteins M Dunne, B Rupf, M Tala, X Qabrati, P Ernst, Y Shen, E Sumrall, L Heeb, ... Cell reports 29 (5), 1336-1350. e4, 2019 | 159 | 2019 |
Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control M Schmid, P Ernst, A Honegger, M Suomalainen, M Zimmermann, ... Nature communications 9 (1), 450, 2018 | 77 | 2018 |
Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity S Hansen, JC Stüber, P Ernst, A Koch, D Bojar, A Batyuk, A Plückthun Scientific reports 7 (1), 16292, 2017 | 55 | 2017 |
Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action F Kast, M Schwill, JC Stüber, S Pfundstein, G Nagy-Davidescu, ... Nature Communications 12 (1), 3790, 2021 | 34 | 2021 |
Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism M Deluigi, A Klipp, C Klenk, L Merklinger, SA Eberle, L Morstein, P Heine, ... Science Advances 7 (5), eabe5504, 2021 | 33 | 2021 |
Chaperone-assisted structure elucidation with DARPins PRE Mittl, P Ernst, A Plückthun Current Opinion in Structural Biology 60, 93-100, 2020 | 26 | 2020 |
Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition C Reichen, S Hansen, C Forzani, A Honegger, SJ Fleishman, T Zhou, ... Journal of Molecular Biology 428 (22), 4467-4489, 2016 | 22 | 2016 |
Structural analysis of biological targets by host: guest crystal lattice engineering P Ernst, A Plückthun, PRE Mittl Scientific reports 9 (1), 1-11, 2019 | 21 | 2019 |
Advances in the design and engineering of peptide-binding repeat proteins P Ernst, A Plückthun Biological chemistry 398 (1), 23-29, 2017 | 18 | 2017 |
An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture M ElGamacy, M Coles, P Ernst, H Zhu, MD Hartmann, A Plückthun, ... ACS synthetic biology 7 (9), 2226-2235, 2018 | 14 | 2018 |
Curvature of designed armadillo repeat proteins allows modular peptide binding AP Simon Hansen, Patrick Ernst, Sebastian LB König, Christian Reichen ... Journal of Structural Biology, 2017 | 14* | 2017 |
Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts P Ernst, A Honegger, F van der Valk, C Ewald, PRE Mittl, A Plückthun Scientific reports 9 (1), 16162, 2019 | 10 | 2019 |
Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation. Nat Commun 8 (1): 45 T Afroz, EM Hock, P Ernst, C Foglieni, M Jambeau, L Gilhespy, ... | 10 | 2017 |
Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization N Friedrich, E Stiegeler, M Glögl, T Lemmin, S Hansen, C Kadelka, Y Wu, ... Nature Communications 12 (1), 6705, 2021 | 9 | 2021 |
Structure-Guided Design of a Peptide Lock for Modular Peptide Binders P Ernst, F Zosel, C Reichen, D Nettels, B Schuler, A Plückthun ACS Chemical Biology 15 (2), 457-468, 2020 | 8 | 2020 |
The M23 peptidase domain of the Staphylococcal phage 2638A endolysin M Dunne, P Ernst, A Sobieraj, A Pluckthun, MJ Loessner (No Title), 2020 | 2 | 2020 |
Unexpected dynamics in femtomolar complexes of binding proteins with peptides S Cucuzza, M Sitnik, S Jurt, E Michel, W Dai, T Müntener, P Ernst, ... Nature communications 14 (1), 7823, 2023 | 1 | 2023 |
Heterodimerization of Endolysin Isoforms During Bacterial Infection by Staphylococcal Phage φ2638A LV Zinsli, AM Sobieraj, P Ernst, S Meile, S Kilcher, C Iseli, A Keller, ... bioRxiv, 2024.01. 16.575832, 2024 | | 2024 |
A DARPin-based toolbox to understand and treat RAS-addicted cancers. JN Kapp, JV Schaefer, W Verdurmen, G Nagy, R Degen, P Ernst, C Scholl, ... MOLECULAR CANCER RESEARCH 18 (5), 66-66, 2020 | | 2020 |