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Fang-Yuan Chang
Fang-Yuan Chang
Ginkgo Bioworks
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Expanding small-molecule functional metagenomics through parallel screening of broad-host-range cosmid environmental DNA libraries in diverse proteobacteria
JW Craig, FY Chang, JH Kim, SC Obiajulu, SF Brady
Applied and environmental microbiology 76 (5), 1633-1641, 2010
2632010
Discovery of reactive microbiota-derived metabolites that inhibit host proteases
CJ Guo, FY Chang, TP Wyche, KM Backus, TM Acker, M Funabashi, ...
Cell 168 (3), 517-526. e18, 2017
2142017
A pressure test to make 10 molecules in 90 days: external evaluation of methods to engineer biology
A Casini, FY Chang, R Eluere, AM King, EM Young, QM Dudley, A Karim, ...
Journal of the American Chemical Society 140 (12), 4302-4316, 2018
1482018
Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening
FY Chang, SF Brady
Proceedings of the National Academy of Sciences 110 (7), 2478-2483, 2013
1242013
Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters
D Montiel, HS Kang, FY Chang, Z Charlop-Powers, SF Brady
Proceedings of the National Academy of Sciences 112 (29), 8953-8958, 2015
1222015
Cloning and characterization of an environmental DNA-derived gene cluster that encodes the biosynthesis of the antitumor substance BE-54017
FY Chang, SF Brady
Journal of the American Chemical Society 133 (26), 9996-9999, 2011
972011
Natural Products from Environmental DNA Hosted in Ralstonia metallidurans
JW Craig, FY Chang, SF Brady
ACS chemical biology 4 (1), 23-28, 2009
972009
Targeted metagenomics: finding rare tryptophan dimer natural products in the environment
FY Chang, MA Ternei, PY Calle, SF Brady
Journal of the American Chemical Society 137 (18), 6044-6052, 2015
572015
Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment
FY Chang, MA Ternei, PY Calle, SF Brady
Journal of the American Chemical Society 135 (47), 17906-17912, 2013
522013
Gut-inhabiting Clostridia build human GPCR ligands by conjugating neurotransmitters with diet-and human-derived fatty acids
FY Chang, P Siuti, S Laurent, T Williams, E Glassey, AW Sailer, ...
Nature microbiology 6 (6), 792-805, 2021
392021
Characterization of an Environmental DNA‐Derived Gene Cluster that Encodes the Bisindolylmaleimide Methylarcyriarubin
FY Chang, SF Brady
ChemBioChem 15 (6), 815-821, 2014
252014
Mutations in the Proteolipid Subunits of the Vacuolar H+-ATPase Provide Resistance to Indolotryptoline Natural Products
FY Chang, SA Kawashima, SF Brady
Biochemistry 53 (45), 7123-7131, 2014
102014
Direct Preparation of Indole Hemiaminals through Organocatalytic Nucleophilic Addition of Indole to Aldehydes
N Zhang, Y Li, Z Chen, W Qin
Synthesis 50 (20), 4063-4070, 2018
42018
Gut-inhabiting Clostridia build human GPCR ligands by conjugating neurotransmitters with diet-and human-derived fatty acids (April, 10.1038/s41564-021-00887-y, 2021)
FY Chang, P Siuti, S Laurent, T Williams, E Glassey, AW Sailer, ...
NATURE MICROBIOLOGY 6 (6), 818-820, 2021
12021
Human gut microbiome-derived biosynthetic enzymes for production of fatty acid amides
CA Voigt, FY Chang
US Patent App. 17/812,156, 2023
2023
Human gut microbiome-derived biosynthetic enzymes for production of fatty acid amides
CA Voigt, FY Chang
US Patent 11,441,162, 2022
2022
Compositions and methods for modulating protease activity
MA Fischbach, CJ Guo, CA Voigt, FY Chang, J Clardy, T Wyche
US Patent 11,124,498, 2021
2021
Metagenomics-Based Tryptophan Dimer Natural Product Discovery and Development Pipeline
FY Chang
2015
Introducing our Authors
T Buchholz, FY Chang, J Craig, T Dasgupta, N Homeyer, H Jenssen, ...
ACS Chemical Biology 4 (1), 4-6, 2009
2009
Sean F Brady
FY Chang
J Am Chem Soc 133 (26), 9996-9999, 0
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Artigos 1–20