Jonathan Kotula
Jonathan Kotula
Synlogic
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Programmable bacteria detect and record an environmental signal in the mammalian gut
JW Kotula, SJ Kerns, LA Shaket, L Siraj, JJ Collins, JC Way, PA Silver
Proceedings of the National Academy of Sciences 111 (13), 4838-4843, 2014
2792014
Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation
DT Riglar, TW Giessen, M Baym, SJ Kerns, MJ Niederhuber, RT Bronson, ...
Nature biotechnology 35 (7), 653-658, 2017
1352017
Aptamer-mediated delivery of splice-switching oligonucleotides to the nuclei of cancer cells
JW Kotula, ED Pratico, X Ming, O Nakagawa, RL Juliano, BA Sullenger
Nucleic acid therapeutics 22 (3), 187-195, 2012
962012
An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans
CB Kurtz, YA Millet, MK Puurunen, M Perreault, MR Charbonneau, ...
Science Translational Medicine 11 (475), 2019
682019
A distributed cell division counter reveals growth dynamics in the gut microbiota
C Myhrvold, JW Kotula, WM Hicks, NJ Conway, PA Silver
Nature communications 6 (1), 1-10, 2015
372015
Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth
JW Kotula, J Sun, M Li, ED Pratico, MP Fereshteh, DP Ahrens, ...
PloS one 9 (4), e93441, 2014
362014
Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns
SH Friend, R Stoughton, Y He
US Patent 7,599,799, 2009
232009
System and method for channel estimation in a radio frequency receiver
DN Banerjee
US Patent 7,286,593, 2007
142007
Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier
D Falb, VM Isabella, JW Kotula, PF Miller
US Patent App. 14/998,376, 2016
102016
Translational Development of Microbiome‐Based Therapeutics: Kinetics of E. coli Nissle and Engineered Strains in Humans and Nonhuman Primates
C Kurtz, WS Denney, L Blankstein, SE Guilmain, S Machinani, J Kotula, ...
Clinical and translational science 11 (2), 200-207, 2018
82018
Bacteria engineered to treat diseases associated with hyperammonemia
D Falb, VM Isabella, JW Kotula, PF Miller, S Machinani
US Patent 9,688,967, 2017
82017
Repeated measures of blood and breath ammonia in response to control, moderate and high protein dose in healthy men
LA Spacek, A Strzepka, S Saha, J Kotula, J Gelb, S Guilmain, T Risby, ...
Scientific Reports 8 (1), 1-8, 2018
52018
Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier
D Falb, VM Isabella, JW Kotula, PF Miller, Y Millet, A Fisher
US Patent App. 15/260,319, 2017
52017
Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
D Falb, JW Kotula, VM Isabella, PF Miller, S Machinani, S Saha, AB Fisher, ...
US Patent App. 16/069,220, 2019
22019
Bacteria engineered to reduce hyperphenylalaninemia
D Falb, VM Isabella, JW Kotula, PF Miller, Y Millet, R Sarah
US Patent 9,943,555, 2018
22018
Bacteria engineered to treat disorders involving the catabolism of a branched chain amino acid
D Falb, PF Miller, Y Millet, VM Isabella, JW Kotula, A Tucker
US Patent App. 15/379,445, 2017
22017
Long-term monitoring of inflammation in the mammalian gut using programmable commensal bacteria
DT Riglar, M Baym, SJ Kerns, MJ Niederhuber, RT Bronson, JW Kotula, ...
BioRxiv, 075051, 2016
22016
Method for discharging sanitary and waste water into separate systems
D Gaynier
US Patent App. 10/047,405, 2003
22003
Bacteria engineered to reduce hyperphenylalaninemia
D Falb, VM Isabella, JW Kotula, PF Miller, Y Millet, R Sarah
US Patent 10,610,546, 2020
12020
Bacteria Engineered to Treat Diseases Associated with Hyperammonemia
D Falb, VM Isabella, JW Kotula, PF Miller, S Machinani
US Patent App. 15/599,285, 2019
12019
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