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Jennifer C. Lee
Jennifer C. Lee
Senior Investigator, National Institutes of Health
E-mail confirmado em mail.nih.gov
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Copper (II) binding to α-synuclein, the Parkinson’s protein
JC Lee, HB Gray, JR Winkler
Journal of the American Chemical Society 130 (22), 6898-6899, 2008
2422008
Biophysics of α-synuclein membrane interactions
CM Pfefferkorn, Z Jiang, JC Lee
Biochimica et Biophysica Acta (BBA)-Biomembranes 1818 (2), 162-171, 2012
2192012
α-Synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases
TL Yap, JM Gruschus, A Velayati, W Westbroek, E Goldin, N Moaven, ...
Journal of Biological Chemistry 286 (32), 28080-28088, 2011
2132011
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein
RP McGlinchey, JC Lee
Proceedings of the National Academy of Sciences 112 (30), 9322-9327, 2015
2112015
α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease
TK Rostovtseva, PA Gurnev, O Protchenko, DP Hoogerheide, TL Yap, ...
Journal of Biological Chemistry 290 (30), 18467-18477, 2015
1802015
α-Synuclein structures from fluorescence energy-transfer kinetics: Implications for the role of the protein in Parkinson's disease
JC Lee, R Langen, PA Hummel, HB Gray, JR Winkler
Proceedings of the National Academy of Sciences of the United States of …, 2004
1782004
α-Synuclein: Stable compact and extended monomeric structures and pH dependence of dimer formation
SL Bernstein, D Liu, T Wyttenbach, MT Bowers, JC Lee, HB Gray, ...
Journal of the American Society for Mass Spectrometry 15 (10), 1435-1443, 2004
1622004
Cytochrome b562 folding triggered by electron transfer: approaching the speed limit for formation of a four-helix-bundle protein
P Wittung-Stafshede, JC Lee, JR Winkler, HB Gray
Proceedings of the National Academy of Sciences 96 (12), 6587-6590, 1999
1561999
Membrane Remodeling by α-Synuclein and Effects on Amyloid Formation
Z Jiang, M de Messieres, JC Lee
Journal of the American Chemical Society 135 (43), 15970-15973, 2013
1342013
Membrane-bound α-synuclein interacts with glucocerebrosidase and inhibits enzyme activity
TL Yap, A Velayati, E Sidransky, JC Lee
Molecular genetics and metabolism 108 (1), 56-64, 2013
1222013
Lipid-chaperone hypothesis: A common molecular mechanism of membrane disruption by intrinsically disordered proteins
MF Sciacca, F Lolicato, C Tempra, F Scollo, BR Sahoo, MD Watson, ...
ACS chemical neuroscience 11 (24), 4336-4350, 2020
1142020
Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17
CM Pfefferkorn, RP McGlinchey, JC Lee
Proceedings of the National Academy of Sciences 107 (50), 21447-21452, 2010
1122010
Structural Insights into α-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations
X Ni, RP McGlinchey, J Jiang, JC Lee
Journal of molecular biology 431 (19), 3913-3919, 2019
1062019
Depth of α-synuclein in a bilayer determined by fluorescence, neutron reflectometry, and computation
CM Pfefferkorn, F Heinrich, AJ Sodt, AS Maltsev, RW Pastor, JC Lee
Biophysical journal 102 (3), 613-621, 2012
1032012
The protein-folding speed limit: intrachain diffusion times set by electron-transfer rates in denatured Ru (NH3) 5 (His-33)-Zn-cytochrome c
IJ Chang, JC Lee, JR Winkler, HB Gray
Proceedings of the National Academy of Sciences 100 (7), 3838-3840, 2003
1022003
Structural features of α-synuclein amyloid fibrils revealed by Raman spectroscopy
JCL JD Flynn, RP McGlinchey, RL Walker
Journal of Biological Chemistry 293, 767-776, 2018
902018
Tryptophan probes at the α-synuclein and membrane interface
CM Pfefferkorn, JC Lee
The Journal of Physical Chemistry B 114 (13), 4615-4622, 2010
902010
Tertiary contact formation in α-synuclein probed by electron transfer
JC Lee, HB Gray, JR Winkler
Journal of the American Chemical Society 127 (47), 16388-16389, 2005
792005
Effects of phosphatidylcholine membrane fluidity on the conformation and aggregation of N-terminally acetylated α-synuclein
EI O'Leary, Z Jiang, MP Strub, JC Lee
Journal of Biological Chemistry 293 (28), 11195-11205, 2018
772018
α-Synuclein tertiary contact dynamics
JC Lee, BT Lai, JJ Kozak, HB Gray, JR Winkler
The Journal of Physical Chemistry B 111 (8), 2107-2112, 2007
762007
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Artigos 1–20