Jared Toettcher
Jared Toettcher
Assistant Professor, Princeton University
E-mail confirmado em princeton.edu - Página inicial
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Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity
LS Weinberger, JC Burnett, JE Toettcher, AP Arkin, DV Schaffer
Cell 122 (2), 169-182, 2005
5832005
Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module
JE Toettcher, OD Weiner, WA Lim
Cell 155 (6), 1422-1434, 2013
3472013
The promise of optogenetics in cell biology: interrogating molecular circuits in space and time
JE Toettcher, CA Voigt, OD Weiner, WA Lim
Nature methods 8 (1), 35-38, 2011
2212011
Light-based feedback for controlling intracellular signaling dynamics
JE Toettcher, D Gong, WA Lim, OD Weiner
Nature methods 8 (10), 837-839, 2011
2122011
Spatiotemporal control of intracellular phase transitions using light-activated optoDroplets
Y Shin, J Berry, N Pannucci, MP Haataja, JE Toettcher, CP Brangwynne
Cell 168 (1-2), 159-171. e14, 2017
2052017
Distinct mechanisms act in concert to mediate cell cycle arrest
JE Toettcher, A Loewer, GJ Ostheimer, MB Yaffe, B Tidor, G Lahav
Proceedings of the National Academy of Sciences 106 (3), 785-790, 2009
1022009
Stimulus design for model selection and validation in cell signaling
JF Apgar, JE Toettcher, D Endy, FM White, B Tidor
PLoS Comput Biol 4 (2), e30, 2008
962008
The spatiotemporal limits of developmental Erk signaling
HE Johnson, Y Goyal, NL Pannucci, T Schüpbach, SY Shvartsman, ...
Developmental cell 40 (2), 185-192, 2017
952017
Optogenetic regulation of engineered cellular metabolism for microbial chemical production
EM Zhao, Y Zhang, J Mehl, H Park, MA Lalwani, JE Toettcher, JL Avalos
Nature 555 (7698), 683-687, 2018
892018
Viral DNA sensors IFI16 and cyclic GMP-AMP synthase possess distinct functions in regulating viral gene expression, immune defenses, and apoptotic responses during herpesvirus …
BA Diner, KK Lum, JE Toettcher, IM Cristea
MBio 7 (6), 2016
792016
A synthetic–natural hybrid oscillator in human cells
JE Toettcher, C Mock, E Batchelor, A Loewer, G Lahav
Proceedings of the National Academy of Sciences 107 (39), 17047-17052, 2010
722010
Mapping local and global liquid phase behavior in living cells using photo-oligomerizable seeds
D Bracha, MT Walls, MT Wei, L Zhu, M Kurian, JL Avalos, JE Toettcher, ...
Cell 175 (6), 1467-1480. e13, 2018
712018
Tracing information flow from Erk to target gene induction reveals mechanisms of dynamic and combinatorial control
MZ Wilson, PT Ravindran, WA Lim, JE Toettcher
Molecular cell 67 (5), 757-769. e5, 2017
682017
Four key steps control glycolytic flux in mammalian cells
LB Tanner, AG Goglia, MH Wei, T Sehgal, LR Parsons, JO Park, E White, ...
Cell systems 7 (1), 49-62. e8, 2018
642018
Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway
LJ Bugaj, AJ Sabnis, A Mitchell, JE Garbarino, JE Toettcher, TG Bivona, ...
Science 361 (6405), 2018
552018
Light control of plasma membrane recruitment using the Phy–PIF system
JE Toettcher, D Gong, WA Lim, OD Weiner
Methods in enzymology 497, 409-423, 2011
462011
Protein phase separation provides long-term memory of transient spatial stimuli
E Dine, AA Gil, G Uribe, CP Brangwynne, JE Toettcher
Cell systems 6 (6), 655-663. e5, 2018
422018
Signaling dynamics control cell fate in the early Drosophila embryo
HE Johnson, JE Toettcher
Developmental cell 48 (3), 361-370. e3, 2019
332019
Gβ regulates coupling between actin oscillators for cell polarity and directional migration
O Hoeller, JE Toettcher, H Cai, Y Sun, CH Huang, M Freyre, M Zhao, ...
PLoS biology 14 (2), e1002381, 2016
292016
Illuminating developmental biology with cellular optogenetics
HE Johnson, JE Toettcher
Current opinion in biotechnology 52, 42-48, 2018
282018
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Artigos 1–20