| Practical methodologies for the synthesis of indoles GR Humphrey, JT Kuethe Chemical reviews 106 (7), 2875-2911, 2006 | 2298 | 2006 |
| Key green chemistry research areas—a perspective from pharmaceutical manufacturers DJC Constable, PJ Dunn, JD Hayler, GR Humphrey, JL Leazer Jr, ... Green Chemistry 9 (5), 411-420, 2007 | 1806 | 2007 |
| Direct conversion of activated alcohols to azides using diphenyl phosphorazidate. A practical alternative to Mitsunobu conditions AS Thompson, GR Humphrey, AM DeMarco, DJ Mathre, EJJ Grabowski The Journal of Organic Chemistry 58 (22), 5886-5888, 1993 | 390 | 1993 |
| Development of a novel, highly efficient halide-catalyzed sulfenylation of indoles M Tudge, M Tamiya, C Savarin, GR Humphrey Organic Letters 8 (4), 565-568, 2006 | 220 | 2006 |
| Highly regioselective Friedländer annulations with unmodified ketones employing novel amine catalysts: Syntheses of 2-substituted quinolines, 1, 8-naphthyridines, and related … PG Dormer, KK Eng, RN Farr, GR Humphrey, JC McWilliams, PJ Reider, ... The Journal of organic chemistry 68 (2), 467-477, 2003 | 168 | 2003 |
| Process development of C–N cross-coupling and enantioselective biocatalytic reactions for the asymmetric synthesis of niraparib CK Chung, PG Bulger, B Kosjek, KM Belyk, N Rivera, ME Scott, ... Organic Process Research & Development 18 (1), 215-227, 2014 | 161 | 2014 |
| Asymmetric synthesis of telcagepant, a CGRP receptor antagonist for the treatment of migraine F Xu, M Zacuto, N Yoshikawa, R Desmond, S Hoerrner, T Itoh, M Journet, ... The Journal of Organic Chemistry 75 (22), 7829-7841, 2010 | 109 | 2010 |
| A ruthenium catalyzed oxidation of steroidal alkenes to enones RA Miller, W Li, GR Humphrey Tetrahedron letters 37 (20), 3429-3432, 1996 | 106 | 1996 |
| Recent applications of α-carbonyl sulfoxonium ylides in rhodium-and iridium-catalyzed C–H functionalizations X Wu, S Sun, JT Yu, J Cheng Synlett 30 (01), 21-29, 2019 | 96 | 2019 |
| Asymmetric synthesis of a potent, aminopiperidine-fused imidazopyridine dipeptidyl peptidase IV inhibitor F Xu, E Corley, M Zacuto, DA Conlon, B Pipik, G Humphrey, J Murry, ... The Journal of Organic Chemistry 75 (5), 1343-1353, 2010 | 67 | 2010 |
| An improved procedure for the preparation of 1‐benzyl‐1H‐1,2,3‐triazoles from benzyl azides IF Cottrell, D Hands, PG Houghton, GR Humphrey, SHB Wright Journal of heterocyclic chemistry 28 (2), 301-304, 1991 | 67 | 1991 |
| A highly regioselective amination of 6-aryl-2, 4-dichloropyrimidine ZH Peng, M Journet, G Humphrey Organic Letters 8 (3), 395-398, 2006 | 66 | 2006 |
| Synthesis of vaniprevir (MK-7009): lactamization to prepare a 22-membered macrocycle ZJ Song, DM Tellers, M Journet, JT Kuethe, D Lieberman, G Humphrey, ... The Journal of Organic Chemistry 76 (19), 7804-7815, 2011 | 63 | 2011 |
| A kinase-cGAS cascade to synthesize a therapeutic STING activator JA McIntosh, Z Liu, BM Andresen, NS Marzijarani, JC Moore, NM Marshall, ... Nature 603 (7901), 439-444, 2022 | 62 | 2022 |
| Enantiospecific and regioselective opening of 2-alkyl nosylaziridines by indoles mediated by boron trifluoride. Application to a practical synthesis of a GnRH antagonist RN Farr, RJ Alabaster, JYL Chung, B Craig, JS Edwards, AW Gibson, ... Tetrahedron: Asymmetry 14 (22), 3503-3515, 2003 | 60 | 2003 |
| Development of a second-generation, highly efficient manufacturing route for the HIV integrase inhibitor raltegravir potassium GR Humphrey, PJ Pye, YL Zhong, R Angelaud, D Askin, KM Belyk, ... Organic Process Research & Development 15 (1), 73-83, 2011 | 59 | 2011 |
| Asymmetric synthesis of letermovir using a novel phase-transfer-catalyzed aza-Michael reaction GR Humphrey, SM Dalby, T Andreani, B Xiang, MR Luzung, ZJ Song, ... Organic Process Research & Development 20 (6), 1097-1103, 2016 | 57 | 2016 |
| The emergence of universal chromatographic methods in the research and development of new drug substances EL Regalado, IA Haidar Ahmad, R Bennett, V D’Atri, AA Makarov, ... Accounts of chemical research 52 (7), 1990-2002, 2019 | 53 | 2019 |
| Enantioselective hydrogenation of α-aryloxy α, β-unsaturated acids. asymmetric synthesis of α-aryloxycarboxylic acids PE Maligres, SW Krska, GR Humphrey Organic Letters 6 (18), 3147-3150, 2004 | 53 | 2004 |
| On the Mechanism of an Asymmetric α,β-Unsaturated Carboxylic Acid Hydrogenation: Application to the Synthesis of a PGD2 Receptor Antagonist DM Tellers, JC McWilliams, G Humphrey, M Journet, L DiMichele, ... Journal of the American Chemical Society 128 (51), 17063-17073, 2006 | 46 | 2006 |
