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Alexander Groffen
Alexander Groffen
Vrije Universiteit en VU Medisch Centrum Amsterdam
Verified email at vu.nl
Title
Cited by
Cited by
Year
Doc2b Is a High-Affinity Ca2+ Sensor for Spontaneous Neurotransmitter Release
AJ Groffen, S Martens, RD Arazola, LN Cornelisse, N Lozovaya, ...
Science 327 (5973), 1614-1618, 2010
3492010
Agrin is a major heparan sulfate proteoglycan in the human glomerular basement membrane
AJ Groffen, MA Ruegg, H Dijkman, TJ Van De Velden, CA Buskens, ...
Journal of Histochemistry & Cytochemistry 46 (1), 19-27, 1998
2371998
Exonic deletions in AUTS2 cause a syndromic form of intellectual disability and suggest a critical role for the C terminus
G Beunders, E Voorhoeve, C Golzio, LM Pardo, JA Rosenfeld, ...
The American Journal of Human Genetics 92 (2), 210-220, 2013
1752013
DOC2A and DOC2B are sensors for neuronal activity with unique calcium‐dependent and kinetic properties
AJA Groffen, R Friedrich, EC Brian, U Ashery, M Verhage
Journal of neurochemistry 97 (3), 818-833, 2006
1222006
Recent insights into the structure and functions of heparan sulfate proteoglycans in the human glomerular basement membrane
AJA Groffen, JH Veerkamp, LAH Monnens, LPWJ Van Den Heuvel
Nephrology Dialysis Transplantation 14 (9), 2119-2129, 1999
1171999
Primary structure and high expression of human agrin in basement membranes of adult lung and kidney
AJA Groffen, CAF Buskens, TH Van Kuppevelt, JH Veerkamp, ...
European journal of biochemistry 254 (1), 123-128, 1998
1021998
Differential expression of agrin in renal basement membranes as revealed by domain-specific antibodies
CJI Raats, MAH Bakker, W Hoch, WPM Tamboer, AJA Groffen, ...
Journal of Biological Chemistry 273 (28), 17832-17838, 1998
1001998
Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?
AM Walter, AJ Groffen, JB Sørensen, M Verhage
Trends in neurosciences 34 (9), 487-497, 2011
812011
DOC2B acts as a calcium switch and enhances vesicle fusion
R Friedrich, AJ Groffen, E Connell, JRT Van Weering, O Gutman, YI Henis, ...
Journal of Neuroscience 28 (27), 6794-6806, 2008
692008
Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain
AJA Groffen, L Jacobsen, D Schut, M Verhage
Journal of neurochemistry 92 (3), 554-568, 2005
692005
Decreased glomerular expression of agrin in diabetic nephropathy and podocytes, cultured in high glucose medium
BA Yard, S Kahlert, R Engelleiter, S Resch, R Waldherr, AJ Groffen, ...
Experimental nephrology 9 (3), 214-222, 2001
662001
Genetic and phenotypic heterogeneity in sporadic and familial forms of paroxysmal dyskinesia
AJA Groffen, T Klapwijk, AF van Rootselaar, JL Groen, MAJ Tijssen
Journal of neurology 260, 93-99, 2013
602013
Ca2+-induced recruitment of the secretory vesicle protein DOC2B to the target membrane
AJA Groffen, EC Brian, JJ Dudok, J Kampmeijer, RF Toonen, M Verhage
Journal of Biological Chemistry 279 (22), 23740-23747, 2004
602004
Doc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivity
L Ramalingam, E Oh, SM Yoder, JT Brozinick, MA Kalwat, AJ Groffen, ...
Diabetes 61 (10), 2424-2432, 2012
512012
Characterization of baculovirus insecticides expressing tailored Bacillus thuringiensis CryIA (b) crystal proteins
JWM Martens, M Knoester, F Weijts, SJA Groffen, Z Hu, D Bosch, JM Vlak
Journal of Invertebrate Pathology 66 (3), 249-257, 1995
511995
Identification of a Dutch founder mutation in MUSK causing fetal akinesia deformation sequence
MB Tan-Sindhunata, IB Mathijssen, M Smit, F Baas, JI De Vries, ...
European Journal of Human Genetics 23 (9), 1151-1157, 2015
482015
DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake
J Li, J Cantley, JG Burchfield, CC Meoli, J Stöckli, PT Whitworth, H Pant, ...
Diabetologia 57, 2173-2182, 2014
462014
TRIM3 regulates the motility of the kinesin motor protein KIF21B
D Labonté, E Thies, Y Pechmann, AJ Groffen, M Verhage, AB Smit, ...
PloS one 8 (9), e75603, 2013
422013
Evidence for the existence of multiple heparan sulfate proteoglycans in the human glomerular basement membrane and mesangial matrix
AJA Groffen, FWH Hop, K Trygovason, H Dijkman, KJM Assmann, ...
European journal of biochemistry 247 (1), 175-182, 1997
391997
Direct quantitative detection of Doc2b-induced hemifusion in optically trapped membranes
I Brouwer, A Giniatullina, N Laurens, JRT Van Weering, D Bald, ...
Nature Communications 6 (1), 8387, 2015
382015
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