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Ayan Ghoshal
Ayan Ghoshal
Stanley Center for Psychiatric Research, Broad Institute
E-mail confirmado em broadinstitute.org
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Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis
A Ghoshal, S Das, S Ghosh, MK Mishra, V Sharma, P Koli, E Sen, A Basu
Glia 55 (5), 483-496, 2007
4102007
Biased mGlu5-positive allosteric modulators provide in vivo efficacy without potentiating mGlu5 modulation of NMDAR currents
JM Rook, Z Xiang, X Lv, A Ghoshal, JW Dickerson, TM Bridges, ...
Neuron 86 (4), 1029-1040, 2015
1282015
Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons
H Tekin, S Simmons, B Cummings, L Gao, X Adiconis, CC Hession, ...
Nature Biomedical Engineering 2 (7), 540-554, 2018
902018
Potentiation of M1 muscarinic receptor reverses plasticity deficits and negative and cognitive symptoms in a schizophrenia mouse model
A Ghoshal, JM Rook, JW Dickerson, GN Roop, RD Morrison, ...
Neuropsychopharmacology 41 (2), 598-610, 2016
772016
Abrogated inflammatory response promotes neurogenesis in a murine model of Japanese encephalitis
S Das, K Dutta, KL Kumawat, A Ghoshal, D Adhya, A Basu
PloS one 6 (3), e17225, 2011
642011
mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome
RG Gogliotti, RK Senter, JM Rook, A Ghoshal, R Zamorano, C Malosh, ...
Human molecular genetics 25 (10), 1990-2004, 2016
562016
The hippocampo-prefrontal pathway: a possible therapeutic target for negative and cognitive symptoms of schizophrenia
A Ghoshal, PJ Conn
Future neurology 10 (2), 115-128, 2015
402015
Effects of a patient-derived de novo coding alteration of CACNA1I in mice connect a schizophrenia risk gene with sleep spindle deficits
A Ghoshal, DS Uygun, L Yang, JM McNally, VG Lopez-Huerta, ...
Translational Psychiatry 10 (1), 29, 2020
262020
Role of mGlu5 Receptors and Inhibitory Neurotransmission in M1 Dependent Muscarinic LTD in the Prefrontal Cortex: Implications in Schizophrenia
A Ghoshal, SP Moran, JW Dickerson, ME Joffe, BA Grueter, Z Xiang, ...
ACS chemical neuroscience 8 (10), 2254-2265, 2017
252017
Early bilateral sensory deprivation blocks the development of coincident discharge in rat barrel cortex
A Ghoshal, P Pouget, M Popescu, F Ebner
Journal of Neuroscience 29 (8), 2384-2392, 2009
222009
mGlu5 Positive Allosteric Modulators Facilitate Long-Term Potentiation via Disinhibition Mediated by mGlu5-Endocannabinoid Signaling
Z Xiang, X Lv, J Maksymetz, BJ Stansley, A Ghoshal, RG Gogliotti, ...
ACS Pharmacology & Translational Science 2 (3), 198-209, 2019
192019
The role of mGlu receptors in hippocampal plasticity deficits in neurological and psychiatric disorders: implications for allosteric modulators as novel therapeutic strategies
R K Senter, A Ghoshal, A G Walker, Z Xiang, C M Niswender, ...
Current neuropharmacology 14 (5), 455-473, 2016
172016
Cross-sensory modulation of primary sensory cortex is developmentally regulated by early sensory experience
A Ghoshal, A Tomarken, F Ebner
Journal of Neuroscience 31 (7), 2526-2536, 2011
142011
Obesity-instructed TREM2high macrophages identified by comparative analysis of diabetic mouse and human kidney at single cell resolution
A Subramanian, K Vernon, Y Zhou, JL Marshall, M Alimova, F Zhang, ...
bioRxiv, 2021.05. 30.446342, 2021
102021
Selective potentiation of M1 muscarinic receptors reverses deficits in plasticity and negative and cognitive symptoms in repeated phencyclidine treated mouse model of schizophrenia
A Ghoshal, J Rook, J Dickerson, G Roop, R Morrison, N Jalan-Sakrikar, ...
Neuropsychopharmacology 41, 598-610, 2016
52016
TAAR1 agonist ulotaront modulates striatal and hippocampal glutamate function in a state-dependent manner
SM Yang, A Ghoshal, JM Hubbard, F Gackière, R Teyssié, SA Neale, ...
Neuropsychopharmacology, 1-13, 2023
22023
Unilateral whisker trimming in newborn rats alters neuronal coincident discharge among mature barrel cortex neurons
A Ghoshal, B Lustig, M Popescu, F Ebner, P Pouget
Journal of Neurophysiology 112 (8), 1925-1935, 2014
12014
Discovery of Metabotropic Glutamate Receptor Subtype 5 PAMs that Display Stimulus Bias Reveals that in Vivo Efficacy in Animal Models can be Achieved Without Direct …
JM Rook, PN Vinson, TM Bridges, SR Stauffer, A Ghoshal, JS Daniels, ...
NEUROPSYCHOPHARMACOLOGY 38, S571-S572, 2013
12013
Methods for treating disorders associated with sleep spindle deficits
Z Fu, JQ Pan, A Ghoshal, G Feng, E Scolnick
US Patent App. 17/610,130, 2022
2022
Discovery of Potentiators of the T-type Calcium Channel Cav3. 3 to Potentially Treat the Sleep Spindle Deficits Observed in Schizophrenia Patients
S Moran, A Ghoshal, J Coleman, M Fitzgerald, D Baez-Nieto, E Yu, ...
NEUROPSYCHOPHARMACOLOGY 46 (SUPPL 1), 328-329, 2021
2021
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