Tamir Chandra
Tamir Chandra
MRC Unit for Human Genetics, IGMM Edinburgh
E-mail confirmado em igmm.ed.ac.uk - Página inicial
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SC3: consensus clustering of single-cell RNA-seq data
VY Kiselev, K Kirschner, MT Schaub, T Andrews, A Yiu, T Chandra, ...
Nature methods 14 (5), 483-486, 2017
7992017
cGAS surveillance of micronuclei links genome instability to innate immunity
KJ Mackenzie, P Carroll, CA Martin, O Murina, A Fluteau, DJ Simpson, ...
Nature 548 (7668), 461-465, 2017
6972017
Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation
T Chandra, K Kirschner, JY Thuret, BD Pope, T Ryba, S Newman, ...
Molecular cell 47 (2), 203-214, 2012
2352012
Global reorganization of the nuclear landscape in senescent cells
T Chandra, PA Ewels, S Schoenfelder, M Furlan-Magaril, SW Wingett, ...
Cell reports 10 (4), 471-483, 2015
2192015
Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence
M Sadaie, R Salama, T Carroll, K Tomimatsu, T Chandra, ARJ Young, ...
Genes & development 27 (16), 1800-1808, 2013
2142013
Single-cell landscape of transcriptional heterogeneity and cell fate decisions during mouse early gastrulation
H Mohammed, I Hernando-Herraez, A Savino, A Scialdone, I Macaulay, ...
Cell reports 20 (5), 1215-1228, 2017
1852017
Efficient targeted DNA methylation with chimeric dCas9–Dnmt3a–Dnmt3L methyltransferase
P Stepper, G Kungulovski, RZ Jurkowska, T Chandra, F Krueger, ...
Nucleic acids research 45 (4), 1703-1713, 2017
1652017
Deletion of the polycomb-group protein EZH2 leads to compromised self-renewal and differentiation defects in human embryonic stem cells
A Collinson, AJ Collier, NP Morgan, AR Sienerth, T Chandra, S Andrews, ...
Cell reports 17 (10), 2700-2714, 2016
842016
Experimental design for single-cell RNA sequencing
J Baran-Gale, T Chandra, K Kirschner
Briefings in functional genomics 17 (4), 233-239, 2018
762018
Direct sequencing of small genomes on the Pacific Biosciences RS without library preparation
P Coupland, T Chandra, M Quail, W Reik, H Swerdlow
Biotechniques 53 (6), 365-372, 2012
582012
Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity
N Olova, DJ Simpson, RE Marioni, T Chandra
Aging cell 18 (1), e12877, 2019
572019
Proliferation drives aging-related functional decline in a subpopulation of the hematopoietic stem cell compartment
K Kirschner, T Chandra, V Kiselev, D Flores-Santa Cruz, IC Macaulay, ...
Cell reports 19 (8), 1503-1511, 2017
542017
High-order chromatin structure and the epigenome in SAHFs
T Chandra, M Narita
Nucleus 4 (1), 23-28, 2013
502013
Chromosome organisation during ageing and senescence
T Chandra, K Kirschner
Current opinion in cell biology 40, 161-167, 2016
452016
Molecular interactions of the type 1 human immunodeficiency virus transregulatory protein Tat with N-methyl-d-aspartate receptor subunits
T Chandra, W Maier, HG König, K Hirzel, D Kögel, T Schüler, A Chandra, ...
Neuroscience 134 (1), 145-153, 2005
452005
An endosiRNA-based repression mechanism counteracts transposon activation during global DNA demethylation in embryonic stem cells
RV Berrens, S Andrews, D Spensberger, F Santos, W Dean, P Gould, ...
Cell stem cell 21 (5), 694-703. e7, 2017
442017
Replication-timing boundaries facilitate cell-type and species-specific regulation of a rearranged human chromosome in mouse
BD Pope, T Chandra, Q Buckley, M Hoare, T Ryba, FK Wiseman, A Kuta, ...
Human molecular genetics 21 (19), 4162-4170, 2012
422012
Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53
K Kirschner, SA Samarajiwa, JM Cairns, S Menon, PA Pérez-Mancera, ...
PLoS genetics 11 (3), e1005053, 2015
392015
Polymer modeling predicts chromosome reorganization in senescence
M Chiang, D Michieletto, CA Brackley, N Rattanavirotkul, H Mohammed, ...
Cell reports 28 (12), 3212-3223. e6, 2019
34*2019
Quantitative assessment of higher‐order chromatin structure of the INK4/ARF locus in human senescent cells
A Hirosue, K Ishihara, K Tokunaga, T Watanabe, N Saitoh, M Nakamoto, ...
Aging cell 11 (3), 553-556, 2012
322012
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