Novel quercetin derivatives: From redox properties to promising treatment of oxidative stress related diseases P Zizkova, M Stefek, L Rackova, M Prnova, L Horakova Chemico-Biological Interactions 265, 36-46, 2017 | 56 | 2017 |
2-Chloro-1, 4-naphthoquinone derivative of quercetin as an inhibitor of aldose reductase and anti-inflammatory agent I Milackova, MS Prnova, M Majekova, R Sotnikova, M Stasko, ... Journal of Enzyme Inhibition and Medicinal Chemistry 30 (1), 107-113, 2015 | 53 | 2015 |
Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold M Stefek, M Soltesova Prnova, M Majekova, C Rechlin, A Heine, G Klebe Journal of Medicinal Chemistry 58 (6), 2649-2657, 2015 | 47 | 2015 |
A novel carboxymethylated mercaptotriazinoindole inhibitor of aldose reductase interferes with the polyol pathway in streptozotocin-induced diabetic rats MS Prnova, J Ballekova, A Gajdosikova, A Gajdosik, M Stefek Physiological Research 64 (4), 587, 2015 | 26 | 2015 |
Cornelian cherry fruit improves glycaemia and manifestations of diabetes in obese Zucker diabetic fatty rats M Capcarova, A Kalafova, M Schwarzova, M Schneidgenova, K Svik, ... Research in veterinary science 126, 118-123, 2019 | 24 | 2019 |
Development of novel oxotriazinoindole inhibitors of aldose reductase: isosteric sulfur/oxygen replacement in the thioxotriazinoindole cemtirestat markedly improved inhibition … M Hlavac, L Kovacikova, MS Prnova, P Sramel, G Addová, M Májeková, ... Journal of Medicinal Chemistry 63 (1), 369-381, 2019 | 22 | 2019 |
Decreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl) phenol as a scaffold for improved membrane permeation M Chatzopoulou, A Patsilinakos, T Vallianatou, MS Prnova, S Žakelj, ... Bioorganic & Medicinal Chemistry 22 (7), 2194-2207, 2014 | 22 | 2014 |
Triglyceride-lowering effect of the aldose reductase inhibitor cemtirestat—another factor that may contribute to attenuation of symptoms of peripheral neuropathy in STZ … MS Prnova, L Kovacikova, K Svik, S Bezek, Z Elmazoğlu, C Karasu, ... Naunyn-Schmiedeberg's Archives of Pharmacology 393, 651-661, 2020 | 21 | 2020 |
3-Mercapto-5H-1,2,4-Triazino[5,6-b]Indole-5-Acetic Acid (Cemtirestat) Alleviates Symptoms of Peripheral Diabetic Neuropathy in Zucker Diabetic Fatty (ZDF) Rats … M Soltesova Prnova, K Svik, S Bezek, L Kovacikova, C Karasu, M Stefek Neurochemical research 44, 1056-1064, 2019 | 21 | 2019 |
Chalcones and their pyrazine analogs: synthesis, inhibition of aldose reductase, antioxidant activity, and molecular docking study M Kucerova-Chlupacova, M Dosedel, J Kunes, M Soltesova-Prnova, ... Monatshefte für Chemie-Chemical Monthly 149, 921-929, 2018 | 21 | 2018 |
Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives MUM Siddique, A Thakur, D Shilkar, S Yasmin, D Halakova, L Kovacikova, ... European journal of medicinal chemistry 223, 113630, 2021 | 19 | 2021 |
3′-O-(3-Chloropivaloyl) quercetin, α-glucosidase inhibitor with multi-targeted therapeutic potential in relation to diabetic complications M Soltesova-Prnova, I Milackova, M Stefek Chemical Papers 70 (11), 1439-1444, 2016 | 19 | 2016 |
Consumption of bee bread influences glycaemia and development of diabetes in obese spontaneous diabetic rats M Capcarova, A Kalafova, M Schwarzova, M Schneidgenova, MS Prnova, ... Biologia 75, 705-711, 2020 | 16 | 2020 |
Antioxidant action of 3-mercapto-5H-1,2,4-triazino[5,6-b]indole-5-acetic acid, an efficient aldose reductase inhibitor, in a 1,1′-diphenyl-2-picrylhydrazyl assay and in the … M Soltesova Prnova, J Ballekova, M Majekova, M Stefek Redox Report 20 (6), 282-288, 2015 | 16 | 2015 |
Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity M Majekova, J Ballekova, M Prnova, M Stefek Bioorganic & Medicinal Chemistry 25 (24), 6353-6360, 2017 | 14 | 2017 |
The consumption of sea buckthorn (Hippophae rhamnoides L.) effectively alleviates type 2 diabetes symptoms in spontaneous diabetic rats R Dupak, J Hrnkova, N Simonova, J Kovac, E Ivanisova, A Kalafova, ... Research in Veterinary Science 152, 261-269, 2022 | 13 | 2022 |
Development of novel indole-based bifunctional aldose reductase inhibitors/antioxidants as promising drugs for the treatment of diabetic complications L Kovacikova, MS Prnova, M Majekova, A Bohac, C Karasu, M Stefek Molecules 26 (10), 2867, 2021 | 12 | 2021 |
(4-Oxo-2-thioxothiazolidin-3-yl) acetic acids as potent and selective aldose reductase inhibitors M Kucerova-Chlupacova, D Halakova, M Majekova, J Treml, M Stefek, ... Chemico-Biological Interactions 332, 109286, 2020 | 11 | 2020 |
Combatting nitrosative stress and inflammation with novel substituted triazinoindole inhibitors of aldose reductase in PC12 cells exposed to 6-hydroxydopamine plus high glucose Z Elmazoglu, MS Prnova, A Santamaria, M Stefek, C Karasu Neurotoxicity Research 39, 210-226, 2021 | 10 | 2021 |
Antioxidant mechanisms in the neuroprotective action of cemtirestat: studies in chemical models, liposomes and rat brain cortical slices MS Prnova, ON Medina-Campos, J Pedraza-Chaverri, AL Colín-González, ... Neuroscience 443, 206-217, 2020 | 10 | 2020 |