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Stephen D Lee
Stephen D Lee
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Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery
KM Wasan, DR Brocks, SD Lee, K Sachs-Barrable, SJ Thornton
Nature Reviews Drug Discovery 7 (1), 84-99, 2008
3352008
Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells
J Sandhu, S Li, L Fairall, SG Pfisterer, JE Gurnett, X Xiao, TA Weston, ...
Cell 175 (2), 514-529. e20, 2018
2112018
Lipid excipients Peceol and Gelucire 44/14 decrease P-glycoprotein mediated efflux of rhodamine 123 partially due to modifying P-glycoprotein protein expression within Caco-2 cells
K Sachs-Barrable, A Thamboo, SD Lee, KM Wasan
J Pharm Pharm Sci 10 (3), 319-331, 2007
1742007
Liver X receptors at the intersection of lipid metabolism and atherogenesis
SD Lee, P Tontonoz
Atherosclerosis 242 (1), 29-36, 2015
1462015
Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes
P Rajbhandari, D Arneson, SK Hart, IS Ahn, G Diamante, LC Santos, ...
Elife 8, e49501, 2019
1362019
Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis
A Briot, M Civelek, A Seki, K Hoi, JJ Mack, SD Lee, J Kim, C Hong, J Yu, ...
Journal of Experimental Medicine 212 (12), 2147-2163, 2015
1052015
Enhancing drug absorption using lipids: a case study presenting the development and pharmacological evaluation of a novel lipid-based oral amphotericin B formulation for the …
K Sachs-Barrable, SD Lee, EK Wasan, SJ Thornton, KM Wasan
Advanced drug delivery reviews 60 (6), 692-701, 2008
962008
Long circulating lipid nanocapsules for drug detoxification
AB Dhanikula, NM Khalid, SD Lee, R Yeung, V Risovic, KM Wasan, ...
Biomaterials 28 (6), 1248-1257, 2007
452007
Eosinophils in fat: pink is the new brown
SD Lee, P Tontonoz
Cell 157 (6), 1249-1250, 2014
422014
RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs
J Wang, P Rajbhandari, A Damianov, A Han, T Sallam, H Waki, ...
The Journal of clinical investigation 127 (3), 987-1004, 2017
362017
Dose-dependent targeted suppression of P-glycoprotein expression and function in Caco-2 cells
SD Lee, JA Osei-Twum, KM Wasan
Molecular pharmaceutics 10 (6), 2323-2330, 2013
302013
The Influence of Hyperlipoproteinemia on in Vitro Distribution of Amiodarone and Desethylamiodarone in Human and Rat Plasma
A Shayeganpour, SD Lee, KM Wasan, DR Brocks
Pharmaceutical research 24, 672-678, 2007
292007
Transgenic Expression of Dominant-Active IDOL in Liver Causes Diet-Induced Hypercholesterolemia and Atherosclerosis in Mice
AC Calkin, SD Lee, J Kim, CMW Van Stijn, XH Wu, AJ Lusis, C Hong, ...
Circulation research 115 (4), 442-449, 2014
262014
Effect of dietary fat on hepatic liver X receptor expression in P-glycoprotein deficient mice: implications for cholesterol metabolism
SJ Thornton, E Wong, SD Lee, KM Wasan
Lipids in Health and Disease 7, 1-7, 2008
242008
Inhibition of cholesterol absorption: targeting the intestine
SD Lee, P Gershkovich, JW Darlington, KM Wasan
Pharmaceutical research 29, 3235-3250, 2012
212012
IDOL regulates systemic energy balance through control of neuronal VLDLR expression
SD Lee, C Priest, M Bjursell, J Gao, DV Arneson, IS Ahn, G Diamante, ...
Nature metabolism 1 (11), 1089-1100, 2019
132019
Evaluation of the contribution of the ATP binding cassette transporter, P-glycoprotein, to in vivo cholesterol homeostasis
SD Lee, SJ Thornton, K Sachs-Barrable, JH Kim, KM Wasan
Molecular pharmaceutics 10 (8), 3203-3212, 2013
102013
Influence of Plasma Cholesterol and Triglyceride Concentrations and Eritoran (E5564) Micelle Size on its Plasma Pharmacokinetics and Ex Vivo Activity Following …
KM Wasan, V Risovic, O Sivak, SD Lee, DX Mason, GR Chiklis, ...
Pharmaceutical research 25, 176-182, 2008
92008
NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice
F Guo, M Seldin, M Péterfy, S Charugundla, Z Zhou, SD Lee, A Mouton, ...
Scientific reports 11 (1), 16409, 2021
62021
The in Vitro Plasma Distribution of a Novel Cholesteryl Ester Transfer Protein Inhibitor, Torcetrapib, Is Influenced by Differences in Plasma Lipid Concentrations
SD Lee, KM Wasan, A Calcagni, M Avery, F McCush, C Chen
Pharmaceutical research 23, 1025-1030, 2006
62006
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