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Rajesh Ramachandran
Rajesh Ramachandran
Associate Professor of Physiology & Biophysics, School of Medicine, Case Western Reserve University
E-mail confirmado em case.edu - Página inicial
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Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission
LD Osellame, AP Singh, DA Stroud, CS Palmer, D Stojanovski, ...
Journal of cell science 129 (11), 2170-2181, 2016
3212016
Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin
R Ramachandran, AP Heuck, RK Tweten, AE Johnson
Nature structural biology 9 (11), 823-827, 2002
2432002
Dissecting dynamin's role in clathrin-mediated endocytosis
M Mettlen, T Pucadyil, R Ramachandran, SL Schmid
Biochemical Society Transactions 37 (5), 1022-1026, 2009
2402009
Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit β-strand alignment
R Ramachandran, RK Tweten, AE Johnson
Nature structural & molecular biology 11 (8), 697-705, 2004
2152004
The dynamin middle domain is critical for tetramerization and higher‐order self‐assembly
R Ramachandran, M Surka, JS Chappie, DM Fowler, TR Foss, BD Song, ...
The EMBO journal 26 (2), 559-566, 2007
2082007
Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomerization
Z Liu, C Wang, J Yang, B Zhou, R Yang, R Ramachandran, DW Abbott, ...
Immunity 51 (1), 43-49. e4, 2019
1782019
Coincident phosphatidic acid interaction restrains Drp1 in mitochondrial division
Y Adachi, K Itoh, T Yamada, KL Cerveny, TL Suzuki, P Macdonald, ...
Molecular cell 63 (6), 1034-1043, 2016
1722016
A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission
PJ Macdonald, N Stepanyants, N Mehrotra, JA Mears, X Qi, H Sesaki, ...
Molecular biology of the cell 25 (12), 1905-1915, 2014
1722014
Cardiolipin's propensity for phase transition and its reorganization by dynamin-related protein 1 form a basis for mitochondrial membrane fission
N Stepanyants, PJ Macdonald, CA Francy, JA Mears, X Qi, ...
Molecular biology of the cell 26 (17), 3104-3116, 2015
1702015
Membrane insertion of the pleckstrin homology domain variable loop 1 is critical for dynamin-catalyzed vesicle scission
R Ramachandran, TJ Pucadyil, YW Liu, S Acharya, M Leonard, ...
Molecular biology of the cell 20 (22), 4630-4639, 2009
1282009
Real‐time detection reveals that effectors couple dynamin's GTP‐dependent conformational changes to the membrane
R Ramachandran, SL Schmid
The EMBO journal 27 (1), 27-37, 2008
1282008
The mechanoenzymatic core of dynamin-related protein 1 comprises the minimal machinery required for membrane constriction
CA Francy, FJD Alvarez, L Zhou, R Ramachandran, JA Mears
Journal of Biological Chemistry 290 (18), 11692-11703, 2015
1232015
The dynamin superfamily
R Ramachandran, S Schmid
Current Biology 28 (8), R411-R416, 2018
1212018
Robust colorimetric assays for dynamin's basal and stimulated GTPase activities
M Leonard, BD Song, R Ramachandran, SL Schmid
Methods in enzymology 404, 490-503, 2005
1192005
Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation
YW Liu, S Neumann, R Ramachandran, SM Ferguson, TJ Pucadyil, ...
Proceedings of the National Academy of Sciences 108 (26), E234-E242, 2011
1112011
The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation
R Ramachandran, RK Tweten, AE Johnson
Proceedings of the National Academy of Sciences 102 (20), 7139-7144, 2005
1092005
Distinct splice variants of dynamin-related protein 1 differentially utilize mitochondrial fission factor as an effector of cooperative GTPase activity
PJ Macdonald, CA Francy, N Stepanyants, L Lehman, A Baglio, JA Mears, ...
Journal of Biological Chemistry 291 (1), 493-507, 2016
952016
Dynamin-related protein 1 oligomerization in solution impairs functional interactions with membrane-anchored mitochondrial fission factor
RW Clinton, CA Francy, R Ramachandran, X Qi, JA Mears
Journal of Biological Chemistry 291 (1), 478-492, 2016
942016
Vesicle scission: dynamin
R Ramachandran
Seminars in cell & developmental biology 22 (1), 10-17, 2011
882011
Mitochondrial dynamics: The dynamin superfamily and execution by collusion
R Ramachandran
Seminars in cell & developmental biology 76, 201-212, 2018
782018
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Artigos 1–20