Najoua Lalaoui
Najoua Lalaoui
Post doc fellow, WEHI
Verified email at
Cited by
Cited by
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism
JM Murphy, PE Czabotar, JM Hildebrand, IS Lucet, JG Zhang, ...
Immunity 39 (3), 443-453, 2013
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis
JA Rickard, JA O’Donnell, JM Evans, N Lalaoui, AR Poh, TW Rogers, ...
Cell 157 (5), 1175-1188, 2014
Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2
D Mérino, N Lalaoui, A Morizot, P Schneider, E Solary, O Micheau
Molecular and cellular biology 26 (19), 7046-7055, 2006
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice
JA Rickard, H Anderton, N Etemadi, U Nachbur, M Darding, N Peltzer, ...
Elife 3, e03464, 2014
TRAIL in cancer therapy: present and future challenges
D Mérino, N Lalaoui, A Morizot, E Solary, O Micheau
Expert opinion on therapeutic targets 11 (10), 1299-1314, 2007
MK2 phosphorylates RIPK1 to prevent TNF-induced cell death
I Jaco, A Annibaldi, N Lalaoui, R Wilson, T Tenev, L Laurien, C Kim, ...
Molecular cell 66 (5), 698-710. e5, 2017
The molecular relationships between apoptosis, autophagy and necroptosis
N Lalaoui, LM Lindqvist, JJ Sandow, PG Ekert
Seminars in cell & developmental biology 39, 63-69, 2015
dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8
Y Estornes, F Toscano, F Virard, G Jacquemin, A Pierrot, B Vanbervliet, ...
Cell Death & Differentiation 19 (9), 1482-1494, 2012
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1-and RIPK3-dependent manner
WWL Wong, JE Vince, N Lalaoui, KE Lawlor, D Chau, A Bankovacki, ...
Blood, The Journal of the American Society of Hematology 123 (16), 2562-2572, 2014
The pseudokinase MLKL and the kinase RIPK3 have distinct roles in autoimmune disease caused by loss of death-receptor-induced apoptosis
S Alvarez-Diaz, CP Dillon, N Lalaoui, MC Tanzer, DA Rodriguez, A Lin, ...
Immunity 45 (3), 513-526, 2016
The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia
G Brumatti, C Ma, N Lalaoui, NY Nguyen, M Navarro, MC Tanzer, ...
Science translational medicine 8 (339), 339ra69-339ra69, 2016
Tumor immune evasion arises through loss of TNF sensitivity
CJ Kearney, SJ Vervoort, SJ Hogg, KM Ramsbottom, AJ Freeman, ...
Science Immunology 3 (23), 2018
Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer
D Merino, JR Whittle, F Vaillant, A Serrano, JN Gong, G Giner, ...
Science translational medicine 9 (401), 2017
Dynamics of HPV16 DNA load reflect the natural history of cervical HPV-associated lesions
S Monnier-Benoit, V Dalstein, D Riethmuller, N Lalaoui, C Mougin, ...
Journal of clinical virology 35 (3), 270-277, 2006
Targeting p38 or MK2 enhances the anti-leukemic activity of Smac-mimetics
N Lalaoui, K Hänggi, G Brumatti, D Chau, NYN Nguyen, L Vasilikos, ...
Cancer cell 29 (2), 145-158, 2016
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
N Lalaoui, SE Boyden, H Oda, GM Wood, DL Stone, D Chau, L Liu, ...
Nature 577 (7788), 103-108, 2020
The TNF receptor superfamily-NF-κB axis is critical to maintain effector regulatory T cells in lymphoid and non-lymphoid tissues
A Vasanthakumar, Y Liao, P Teh, MF Pascutti, AE Oja, AL Garnham, ...
Cell reports 20 (12), 2906-2920, 2017
TRAIL-R4 promotes tumor growth and resistance to apoptosis in cervical carcinoma HeLa cells through AKT
N Lalaoui, A Morlé, D Mérino, G Jacquemin, E Iessi, A Morizot, S Shirley, ...
PloS one 6 (5), e19679, 2011
Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin’s lymphoma B cells
G Jacquemin, V Granci, AS Gallouet, N Lalaoui, A Morlé, E Iessi, ...
Haematologica 97 (1), 38, 2012
Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level
A Morizot, D Mérino, N Lalaoui, G Jacquemin, V Granci, E Iessi, ...
Cell Death & Differentiation 18 (4), 700-711, 2011
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