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Robyn Rebbeck
Robyn Rebbeck
E-mail confirmado em umn.edu
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Skeletal muscle excitation–contraction coupling: who are the dancing partners?
RT Rebbeck, Y Karunasekara, PG Board, NA Beard, MG Casarotto, ...
The international journal of biochemistry & cell biology 48, 28-38, 2014
1332014
High-throughput screens to discover small-molecule modulators of ryanodine receptor calcium release channels
RT Rebbeck, MM Essawy, FR Nitu, BD Grant, GD Gillispie, DD Thomas, ...
SLAS DISCOVERY: Advancing Life Sciences R&D 22 (2), 176-186, 2017
612017
The β1a subunit of the skeletal DHPR binds to skeletal RyR1 and activates the channel via its 35-residue C-terminal tail
RT Rebbeck, Y Karunasekara, EM Gallant, PG Board, NA Beard, ...
Biophysical journal 100 (4), 922-930, 2011
562011
Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic
SM Batiste, DJ Blackwell, K Kim, DO Kryshtal, N Gomez-Hurtado, ...
Proceedings of the National Academy of Sciences 116 (11), 4810-4815, 2019
472019
The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1. 5 and RyR2 function
CN Johnson, R Pattanayek, F Potet, RT Rebbeck, DJ Blackwell, ...
Cell Calcium 82, 102063, 2019
452019
S100A1 protein does not compete with calmodulin for ryanodine receptor binding but structurally alters the ryanodine receptor· calmodulin complex
RT Rebbeck, FR Nitu, D Rohde, P Most, DM Bers, DD Thomas, ...
Journal of Biological Chemistry 291 (30), 15896-15907, 2016
382016
Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators
A Lindsay, CW Baumann, RT Rebbeck, SL Yuen, WM Southern, ...
Skeletal muscle 10, 1-14, 2020
352020
RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays
RT Rebbeck, DP Singh, KA Janicek, DM Bers, DD Thomas, ...
Scientific reports 10 (1), 1791, 2020
312020
Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814
K Walweel, N Gomez-Hurtado, RT Rebbeck, YW Oo, NA Beard, ...
Journal of molecular and cellular cardiology 130, 96-106, 2019
242019
An α‐helical C‐terminal tail segment of the skeletal L‐type Ca2+ channel β1a subunit activates ryanodine receptor type 1 via a hydrophobic surface
Y Karunasekara, RT Rebbeck, LM Weaver, PG Board, AF Dulhunty, ...
The FASEB Journal 26 (12), 5049-5059, 2012
222012
β1a490–508, a 19-residue peptide from C-terminal tail of Cav1. 1 β1a subunit, potentiates voltage-dependent calcium release in adult skeletal muscle fibers
EO Hernández-Ochoa, RO Olojo, RT Rebbeck, AF Dulhunty, ...
Biophysical journal 106 (3), 535-547, 2014
172014
A large-scale high-throughput screen for modulators of SERCA activity
PA Bidwell, SL Yuen, J Li, K Berg, RT Rebbeck, CC Aldrich, ...
Biomolecules 12 (12), 1789, 2022
112022
The functional significance of redox-mediated intersubunit cross-linking in regulation of human type 2 ryanodine receptor
R Nikolaienko, E Bovo, RT Rebbeck, D Kahn, DD Thomas, RL Cornea, ...
Redox Biology 37, 101729, 2020
112020
Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit
RT Rebbeck, H Willemse, L Groom, MG Casarotto, PG Board, NA Beard, ...
Skeletal muscle 5, 1-15, 2015
92015
Synergistic FRET assays for drug discovery targeting RyR2 channels
RT Rebbeck, KS Ginsburg, CY Ko, A Fasoli, K Rusch, GF Cai, X Dong, ...
Journal of molecular and cellular cardiology 168, 13-23, 2022
82022
Novel drug discovery platform for spinocerebellar ataxia, using fluorescence technology targeting β-III-spectrin
RT Rebbeck, AK Andrick, SA Denha, B Svensson, P Guhathakurta, ...
Journal of Biological Chemistry 296, 2021
82021
CaMKIIδ post-translational modifications increase affinity for calmodulin inside cardiac ventricular myocytes
M Simon, CY Ko, RT Rebbeck, S Baidar, RL Cornea, DM Bers
Journal of molecular and cellular cardiology 161, 53-61, 2021
42021
Fluorescence lifetime FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators
O Roopnarine, SL Yuen, AR Thompson, LN Roelike, RT Rebbeck, ...
Scientific reports 13 (1), 10673, 2023
32023
Early-phase drug discovery of β-III-spectrin actin-binding modulators for treatment of spinocerebellar ataxia type 5
P Guhathakurta, RT Rebbeck, SA Denha, AR Keller, AL Carter, AE Atang, ...
Journal of Biological Chemistry 299 (3), 2023
32023
Interactions between dihydropyridine β1A subunit and ryanodine receptor isoforms
RT Rebbeck, H Willemse, L Groom, RT Dirksen, AF Dulhunty
Biophysical Journal 104 (2), 105a, 2013
22013
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Artigos 1–20