| Modulation of γ-secretase reduces β-amyloid deposition in a transgenic mouse model of Alzheimer's disease MZ Kounnas, AM Danks, S Cheng, C Tyree, E Ackerman, X Zhang, K Ahn, ... Neuron 67 (5), 769-780, 2010 | 289 | 2010 |
| Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of … MR Minter, R Hinterleitner, M Meisel, C Zhang, V Leone, X Zhang, ... Scientific reports 7 (1), 10411, 2017 | 237 | 2017 |
| Activation and intrinsic γ-secretase activity of presenilin 1 K Ahn, CC Shelton, Y Tian, X Zhang, ML Gilchrist, SS Sisodia, YM Li Proceedings of the National Academy of Sciences 107 (50), 21435-21440, 2010 | 186 | 2010 |
| Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes HB Dodiya, T Kuntz, SM Shaik, C Baufeld, J Leibowitz, X Zhang, N Gottel, ... Journal of Experimental Medicine 216 (7), 1542-1560, 2019 | 182 | 2019 |
| A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2 X Zhang, K Garbett, K Veeraraghavalu, B Wilburn, R Gilmore, K Mirnics, ... Journal of Neuroscience 32 (25), 8633-8648, 2012 | 126 | 2012 |
| Selective disruption of “late onset” sagittal banding patterns by ectopic expression of engrailed-2 in cerebellar Purkinje cells SL Baader, MW Vogel, S Sanlioglu, X Zhang, J Oberdick Journal of Neuroscience 19 (13), 5370-5379, 1999 | 76 | 1999 |
| Evidence That CD147 Modulation of β-Amyloid (Aβ) Levels Is Mediated by Extracellular Degradation of Secreted Aβ*♦ KS Vetrivel, X Zhang, X Meckler, H Cheng, S Lee, P Gong, KO Lopes, ... Journal of biological chemistry 283 (28), 19489-19498, 2008 | 70 | 2008 |
| Structure of γ-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy F Renzi, X Zhang, WJ Rice, C Torres-Arancivia, Y Gomez-Llorente, ... Journal of Biological Chemistry 286 (24), 21440-21449, 2011 | 52 | 2011 |
| Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated … SL Wagner, C Zhang, S Cheng, P Nguyen, X Zhang, KD Rynearson, ... Biochemistry 53 (4), 702-713, 2014 | 51 | 2014 |
| Conservation of the developmentally regulated dendritic localization of a Purkinje cell-specific mRNA that encodes a G-protein modulator: comparison of rodent and human Pcp2 … X Zhang, H Zhang, J Oberdick Molecular brain research 105 (1-2), 1-10, 2002 | 47 | 2002 |
| Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies X Zhang, RJ Hoey, G Lin, A Koide, B Leung, K Ahn, G Dolios, M Paduch, ... Proceedings of the National Academy of Sciences 109 (22), 8534-8539, 2012 | 44 | 2012 |
| Acne inversa caused by missense mutations in NCSTN is not fully compatible with impairments in Notch signaling X Zhang, SS Sisodia The Journal of investigative dermatology 135 (2), 618-620, 2015 | 35 | 2015 |
| High level Purkinje cell specific expression of green fluorescent protein in transgenic mice X Zhang, SL Baader, F Bian, W Müller, J Oberdick Histochemistry and cell biology 115, 455-464, 2001 | 33 | 2001 |
| Regulation of a Purkinje cell‐specific promoter by homeodomain proteins: Repression by Engrailed‐2 vs. synergistic activation by Hoxa5 and Hoxb7 S Sanlioglu, X Zhang, SL Baader, J Oberdick Journal of neurobiology 36 (4), 559-571, 1998 | 29 | 1998 |
| The topology of pen-2, a γ-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain X Zhang, CJ Yu, SS Sisodia Molecular Neurodegeneration 10, 1-8, 2015 | 21 | 2015 |
| A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase X Zhang, R Hoey, A Koide, G Dolios, M Paduch, P Nguyen, X Wu, Y Li, ... Journal of Biological Chemistry 289 (50), 34851-34861, 2014 | 12 | 2014 |
| An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo X Zhang, CM Zhang, D Prokopenko, Y Liang, SY Zhen, IQ Weigle, W Han, ... Journal of Experimental Medicine 218 (6), e20210313, 2021 | 8 | 2021 |
| Negative evidence for a role of APH1B T27I variant in Alzheimer’s disease X Zhang, C Zhang, D Prokopenko, Y Liang, W Han, RE Tanzi, SS Sisodia Human Molecular Genetics 29 (6), 955-966, 2020 | 8 | 2020 |
| Evidence that the “Lid” domain of nicastrin is not essential for regulating γ-secretase activity X Zhang, E Sullivan, M Scimeca, X Wu, Y Li, SS Sisodia Journal of Biological Chemistry 291 (13), 6748-6753, 2016 | 7 | 2016 |
| 3′ UTR-dependent localization of a Purkinje cell messenger RNA in dendrites R Zhang, X Zhang, F Bian, X Pu, K Schilling, J Oberdick The Cerebellum 7, 482-493, 2008 | 6 | 2008 |
