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Georgina S. Butler
Georgina S. Butler
Research Associate, Center for Blood Research, University of British Columbia, Canada.
E-mail confirmado em ubc.ca
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Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1
GA McQuibban, GS Butler, JH Gong, L Bendall, C Power, I Clark-Lewis, ...
Journal of Biological Chemistry 276 (47), 43503-43508, 2001
7812001
The TIMP2 membrane type 1 metalloproteinase “receptor” regulates the concentration and efficient activation of progelatinase A: a kinetic study
GS Butler, MJ Butler, SJ Atkinson, H Will, T Tamura, SS van Westrum, ...
Journal of Biological Chemistry 273 (2), 871-880, 1998
7591998
The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation: regulation by TIMP …
H Will, SJ Atkinson, GS Butler, B Smith, G Murphy
Journal of Biological Chemistry 271 (29), 17119-17123, 1996
7111996
Mechanisms for pro matrix metalloproteinase activation
G Murphy, H Stanton, S Cowell, G Butler, V KNÄUPER, S ATKINSON, ...
Apmis 107 (1‐6), 38-44, 1999
6011999
Membrane‐type matrix metalloproteinases 1 and 2 exhibit broad‐spectrum proteolytic capacities comparable to many matrix metalloproteinases
MP D'ortho, H Will, S Atkinson, G Butler, A Messent, J Gavrilovic, B Smith, ...
European journal of biochemistry 250 (3), 751-757, 1997
5631997
HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration
K Zhang, GA McQuibban, C Silva, GS Butler, JB Johnston, J Holden, ...
Nature neuroscience 6 (10), 1064-1071, 2003
3712003
Matrix metalloproteinase proteomics: substrates, targets, and therapy
CJ Morrison, GS Butler, D Rodríguez, CM Overall
Current opinion in cell biology 21 (5), 645-653, 2009
3132009
Multiplex N-terminome analysis of MMP-2 and MMP-9 substrate degradomes by iTRAQ-TAILS quantitative proteomics
A Prudova, U auf dem Keller, GS Butler, CM Overall
Molecular & Cellular Proteomics 9 (5), 894-911, 2010
3092010
Updated biological roles for matrix metalloproteinases and new “intracellular” substrates revealed by degradomics
GS Butler, CM Overall
Biochemistry 48 (46), 10830-10845, 2009
2802009
A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity
DJ Marchant, CL Bellac, TJ Moraes, SJ Wadsworth, A Dufour, GS Butler, ...
Nature medicine 20 (5), 493-502, 2014
2572014
Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway
CJ Morrison, GS Butler, HF Bigg, CR Roberts, PD Soloway, CM Overall
Journal of Biological Chemistry 276 (50), 47402-47410, 2001
2462001
Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth …
RA Dean, GS Butler, Y Hamma-Kourbali, J Delbé, DR Brigstock, J Courty, ...
Molecular and cellular biology 27 (24), 8454-8465, 2007
2432007
Membrane‐type‐2 matrix metalloproteinase can initiate the processing of progelatinase A and is regulated by the tissue inhibitors of metalloproteinases
GS Butler, H Will, SJ Atkinson, G Murphy
European Journal of Biochemistry 244 (2), 653-657, 1997
2211997
Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic …
U Eckhard, PF Huesgen, O Schilling, CL Bellac, GS Butler, JH Cox, ...
Matrix biology 49, 37-60, 2016
2082016
Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase
HF Bigg, CJ Morrison, GS Butler, MA Bogoyevitch, Z Wang, PD Soloway, ...
Cancer research 61 (9), 3610-3618, 2001
1972001
Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding
GS Butler, RA Dean, EM Tam, CM Overall
Molecular and cellular biology 28 (15), 4896-4914, 2008
1902008
Characterization of the distinct collagen binding, helicase and cleavage mechanisms of matrix metalloproteinase 2 and 14 (gelatinase A and MT1-MMP): the differential roles of …
EM Tam, TR Moore, GS Butler, CM Overall
Journal of Biological Chemistry 279 (41), 43336-43344, 2004
1852004
Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain: the ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits …
EM Tam, YI Wu, GS Butler, MS Stack, CM Overall
Journal of Biological Chemistry 277 (41), 39005-39014, 2002
1722002
Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome
A Doucet, GS Butler, D Rodriáguez, A Prudova, CM Overall
Molecular & Cellular Proteomics 7 (10), 1925-1951, 2008
1712008
New intracellular activities of matrix metalloproteinases shine in the moonlight
PG Jobin, GS Butler, CM Overall
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1864 (11), 2043-2055, 2017
1692017
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