Jason D. Hughes
Jason D. Hughes
Computational Biologist, Merck
E-mail confirmado em merck.com
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Systematic determination of genetic network architecture
S Tavazoie, JD Hughes, MJ Campbell, RJ Cho, GM Church
Nature genetics 22 (3), 281-285, 1999
30041999
Computational identification of cis-regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae
JD Hughes, PW Estep, S Tavazoie, GM Church
Journal of molecular biology 296 (5), 1205-1214, 2000
12752000
Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitation
FP Roth, JD Hughes, PW Estep, GM Church
Nature biotechnology 16 (10), 939-945, 1998
11901998
Activated STING in a vascular and pulmonary syndrome
Y Liu, AA Jesus, B Marrero, D Yang, SE Ramsey, ...
New England Journal of Medicine 371 (6), 507-518, 2014
6362014
Physiochemical drug properties associated with in vivo toxicological outcomes
JD Hughes, J Blagg, DA Price, S Bailey, GA DeCrescenzo, RV Devraj, ...
Bioorganic & medicinal chemistry letters 18 (17), 4872-4875, 2008
6102008
A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression
BA Cohen, RD Mitra, JD Hughes, GM Church
Nature genetics 26 (2), 183-186, 2000
5722000
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
HS Kuehn, W Ouyang, B Lo, EK Deenick, JE Niemela, DT Avery, ...
Science 345 (6204), 1623-1627, 2014
5542014
Software distribution system to build and distribute a software release
N Shing, L Erlikh, NR Lim, JL Lambert, JM Moskowitz, VK Wadhwa, ...
US Patent 5,495,610, 1996
5521996
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ...
Nature genetics 51 (3), 414-430, 2019
4012019
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
R Sims, SJ Van Der Lee, AC Naj, C Bellenguez, N Badarinarayan, ...
Nature genetics 49 (9), 1373-1384, 2017
3912017
Are protein–protein interfaces more conserved in sequence than the rest of the protein surface?
DR Caffrey, S Somaroo, JD Hughes, J Mintseris, ES Huang
Protein Science 13 (1), 190-202, 2004
3872004
Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy
B Lo, K Zhang, W Lu, L Zheng, Q Zhang, C Kanellopoulou, Y Zhang, Z Liu, ...
Science 349 (6246), 436-440, 2015
3622015
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
JD Milner, TP Vogel, L Forbes, CA Ma, A Stray-Pedersen, JE Niemela, ...
Blood 125 (4), 591-599, 2015
3052015
Conservation of DNA regulatory motifs and discovery of new motifs in microbial genomes
AM McGuire, JD Hughes, GM Church
Genome research 10 (6), 744-757, 2000
2582000
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
D Nepogodiev, JC Glasbey, E Li, OM Omar, JFF Simoes, TEF Abbott, ...
The Lancet, 2020
2372020
Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K
CL Lucas, Y Zhang, A Venida, Y Wang, J Hughes, J McElwee, M Butrick, ...
Journal of Experimental Medicine 211 (13), 2537-2547, 2014
1662014
Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment
Y Zhang, X Yu, M Ichikawa, JJ Lyons, S Datta, IT Lamborn, H Jing, ES Kim, ...
Journal of Allergy and Clinical Immunology 133 (5), 1400-1409. e5, 2014
1582014
Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number
JJ Lyons, X Yu, JD Hughes, QT Le, A Jamil, Y Bai, N Ho, M Zhao, Y Liu, ...
Nature genetics 48 (12), 1564-1569, 2016
1142016
Computer-aided software engineering facility
VK Wadhwa, F Ataie, VP Aubrun, L Erlikh, M Fischer, M Fochler, ...
US Patent 5,295,222, 1994
1101994
siRNA off-target effects can be reduced at concentrations that match their individual potency
DR Caffrey, J Zhao, Z Song, ME Schaffer, SA Haney, RR Subramanian, ...
PloS one 6 (7), e21503, 2011
1012011
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