John Kopchick
John Kopchick
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A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)
Y Zhou, BC Xu, HG Maheshwari, L He, M Reed, M Lozykowski, S Okada, ...
Proceedings of the National Academy of Sciences 94 (24), 13215-13220, 1997
Assessment of growth parameters and life span of GHR/BP gene-disrupted mice
KT Coschigano, D Clemmons, LL Bellush, JJ Kopchick
Endocrinology 141 (7), 2608-2613, 2000
Growth hormone antagonists
JJ Kopchick, WY Chen
US Patent 5,350,836, 1994
Interventions to slow aging in humans: are we ready?
VD Longo, A Antebi, A Bartke, N Barzilai, HM Brown‐Borg, C Caruso, ...
Aging cell 14 (4), 497-510, 2015
Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased …
KT Coschigano, AN Holland, ME Riders, EO List, A Flyvbjerg, JJ Kopchick
Endocrinology 144 (9), 3799-3810, 2003
Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression
CW Cheng, GB Adams, L Perin, M Wei, X Zhou, BS Lam, S Da Sacco, ...
Cell stem cell 14 (6), 810-823, 2014
Essential role of growth hormone in ischemia-induced retinal neovascularization
LEH Smith, JJ Kopchick, W Chen, J Knapp, F Kinose, D Daley, E Foley, ...
Science 276 (5319), 1706-1709, 1997
The GH/IGF-1 axis in ageing and longevity
RK Junnila, EO List, DE Berryman, JW Murrey, JJ Kopchick
Nature Reviews Endocrinology 9 (6), 366-376, 2013
Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly
JJ Kopchick, C Parkinson, EC Stevens, PJ Trainer
Endocrine reviews 23 (5), 623-646, 2002
Growth Hormone Research Society workshop summary: consensus guidelines for recombinant human growth hormone therapy in Prader-Willi syndrome
CL Deal, M Tony, C Höybye, DB Allen, M Tauber, JS Christiansen, ...
The Journal of Clinical Endocrinology & Metabolism 98 (6), E1072-E1087, 2013
Growth hormone (GH), GH receptor, and signal transduction
JJ Kopchick, JM Andry
Molecular genetics and metabolism 71 (1-2), 293-314, 2000
Comparing adiposity profiles in three mouse models with altered GH signaling
DE Berryman, EO List, KT Coschigano, K Behar, JK Kim, JJ Kopchick
Growth Hormone & IGF Research 14 (4), 309-318, 2004
Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models
DE Berryman, JS Christiansen, G Johannsson, MO Thorner, JJ Kopchick
Growth Hormone & IGF Research 18 (6), 455-471, 2008
Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects
MI Gallego, N Binart, GW Robinson, R Okagaki, KT Coschigano, J Perry, ...
Developmental biology 229 (1), 163-175, 2001
Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1–deficient mice
S Yakar, J Setser, H Zhao, B Stannard, M Haluzik, V Glatt, ML Bouxsein, ...
The Journal of clinical investigation 113 (1), 96-105, 2004
Identification and expression of mammalian long-chain PUFA elongation enzymes
AE Leonard, B Kelder, EG Bobik, LT Chuang, CJ Lewis, JJ Kopchick, ...
Lipids 37, 733-740, 2002
Liver-specific Deletion of the Growth Hormone Receptor Reveals Essential Role of Growth Hormone Signaling in Hepatic Lipid Metabolism*♦
Y Fan, RK Menon, P Cohen, D Hwang, T Clemens, DJ DiGirolamo, ...
Journal of Biological Chemistry 284 (30), 19937-19944, 2009
Expression of a mutated bovine growth hormone gene suppresses growth of transgenic mice.
WY Chen, DC Wight, TE Wagner, JJ KoPCHICK
Proceedings of the National Academy of Sciences 87 (13), 5061-5065, 1990
Bone homeostasis in growth hormone receptor–null mice is restored by IGF-I but independent of Stat5
NA Sims, P Clément-Lacroix, F Da Ponte, Y Bouali, N Binart, R Moriggl, ...
The Journal of clinical investigation 106 (9), 1095-1103, 2000
A consensus on the diagnosis and treatment of acromegaly comorbidities: an update
A Giustina, A Barkan, A Beckers, N Biermasz, BMK Biller, C Boguszewski, ...
The Journal of Clinical Endocrinology & Metabolism 105 (4), e937-e946, 2020
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