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Lina Schiffer
Lina Schiffer
Postdoctoral Research Fellow, University of Birmingham
E-mail confirmado em bham.ac.uk
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Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review
L Schiffer, L Barnard, ES Baranowski, LC Gilligan, AE Taylor, W Arlt, ...
The Journal of steroid biochemistry and molecular biology 194, 105439, 2019
1292019
Intracrine androgen biosynthesis, metabolism and action revisited
L Schiffer, W Arlt, KH Storbeck
Molecular and Cellular Endocrinology 465, 4-26, 2018
1152018
Mechanisms in endocrinology: the sexually dimorphic role of androgens in human metabolic disease
L Schiffer, P Kempegowda, W Arlt, MW O’Reilly
European journal of endocrinology 177 (3), R125-R143, 2017
1042017
The CYP11B subfamily
L Schiffer, S Anderko, F Hannemann, A Eiden-Plach, R Bernhardt
The Journal of Steroid Biochemistry and Molecular Biology 151, 38-51, 2015
502015
Steroid metabolome analysis in disorders of adrenal steroid biosynthesis and metabolism
KH Storbeck, L Schiffer, ES Baranowski, V Chortis, A Prete, L Barnard, ...
Endocrine reviews 40 (6), 1605-1625, 2019
492019
A recombinant CYP11B1 dependent Escherichia coli biocatalyst for selective cortisol production and optimization towards a preparative scale
L Schiffer, S Anderko, A Hobler, F Hannemann, N Kagawa, R Bernhardt
Microbial cell factories 14 (1), 1-12, 2015
342015
Metabolism of oral turinabol by human steroid hormone–synthesizing cytochrome P450 enzymes
L Schiffer, S Brixius-Anderko, F Hannemann, J Zapp, J Neunzig, M Thevis, ...
Drug Metabolism and Disposition 44 (2), 227-237, 2016
272016
A CYP21A2 based whole-cell system in Escherichia coli for the biotechnological production of premedrol
S Brixius-Anderko, L Schiffer, F Hannemann, B Janocha, R Bernhardt
Microbial cell factories 14 (1), 1-14, 2015
262015
The steroid metabolite 16 (β)-OH-androstenedione generated by CYP21A2 serves as a substrate for CYP19A1
J Neunzig, M Milhim, L Schiffer, Y Khatri, J Zapp, A Sanchez-Guijo, ...
The Journal of Steroid Biochemistry and Molecular Biology 167, 182-191, 2017
232017
Measurement of salivary adrenal-specific androgens as biomarkers of therapy control in 21-hydroxylase deficiency
I Bacila, J Adaway, J Hawley, S Mahdi, R Krone, L Patel, S Alvi, T Randell, ...
The Journal of Clinical Endocrinology & Metabolism 104 (12), 6417-6429, 2019
192019
Understanding the role of androgen action in female adipose tissue
L Schiffer, W Arlt, MW O’Reilly
Hyperandrogenism in women 53, 33-49, 2019
172019
Biotransformation of the mineralocorticoid receptor antagonists spironolactone and canrenone by human CYP11B1 and CYP11B2: characterization of the products and their influence …
L Schiffer, AR Müller, A Hobler, S Brixius-Anderko, J Zapp, F Hannemann, ...
The Journal of steroid biochemistry and molecular biology 163, 68-76, 2016
132016
11-Oxygenated estrogens are a novel class of human estrogens but do not contribute to the circulating estrogen pool
L Barnard, L Schiffer, R Louw du-Toit, JA Tamblyn, S Chen, D Africander, ...
Endocrinology 162 (3), bqaa231, 2021
92021
The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1
L Barnard, N Nikolaou, C Louw, L Schiffer, H Gibson, LC Gilligan, ...
The Journal of steroid biochemistry and molecular biology 202, 105724, 2020
82020
Intracrine testosterone activation in human pancreatic β-cells stimulates insulin secretion
W Xu, L Schiffer, MMF Qadir, Y Zhang, J Hawley, P Mota De Sa, ...
Diabetes 69 (11), 2392-2399, 2020
62020
A liquid chromatography-tandem mass spectrometry assay for the profiling of classical and 11-oxygenated androgens in saliva
L Schiffer, JE Adaway, W Arlt, BG Keevil
Annals of Clinical Biochemistry 56 (5), 564-573, 2019
62019
A novel high-throughput assay for the measurement of salivary progesterone by liquid chromatography tandem mass spectrometry
L Schiffer, JE Adaway, ES Baranowski, W Arlt, BG Keevil
Annals of Clinical Biochemistry 56 (1), 64-71, 2019
52019
Peripheral blood mononuclear cells preferentially activate 11-oxygenated androgens
L Schiffer, A Bossey, P Kempegowda, AE Taylor, I Akerman, ...
European Journal of Endocrinology 184 (3), 353-363, 2021
22021
Intracrine activation of 11-oxygenated androgens by AKR1C3 modulates lipid metabolism in human female adipose tissue
L Schiffer, AJ Sinclair, WO Michael, C Westgate, A Mashood, E Palmer, ...
Endocrine Abstracts 65, 2019
12019
Timed urinary steroid profiling of patients with different degrees of cortisol excess: a proposal for a new test for the diagnosis of Cushing
A Prete, AE Taylor, L Schiffer, M Nestola, L Pignata, SM Corsello, W Arlt
Endocrine Abstracts 59, 2018
12018
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