| MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition RC Coll, JR Hill, CJ Day, A Zamoshnikova, D Boucher, NL Massey, ... Nature chemical biology 15 (6), 556-559, 2019 | 654 | 2019 |
| Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps KW Chen, M Monteleone, D Boucher, G Sollberger, D Ramnath, ... Science immunology 3 (26), eaar6676, 2018 | 491 | 2018 |
| Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity D Boucher, M Monteleone, RC Coll, KW Chen, CM Ross, JL Teo, ... Journal of Experimental Medicine 215 (3), 827-840, 2018 | 466 | 2018 |
| NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5 PJ Baker, D Boucher, D Bierschenk, C Tebartz, PG Whitney, DB D'Silva, ... European journal of immunology 45 (10), 2918-2926, 2015 | 351 | 2015 |
| Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and-independent secretion M Monteleone, AC Stanley, KW Chen, DL Brown, JS Bezbradica, ... Cell reports 24 (6), 1425-1433, 2018 | 270 | 2018 |
| Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria JC Santos, D Boucher, LK Schneider, B Demarco, M Dilucca, K Shkarina, ... Nature communications 11 (1), 3276, 2020 | 205 | 2020 |
| Caspase-7 uses an exosite to promote poly (ADP ribose) polymerase 1 proteolysis D Boucher, V Blais, JB Denault Proceedings of the National Academy of Sciences 109 (15), 5669-5674, 2012 | 129 | 2012 |
| Inflammatory caspases: toward a unified model for caspase activation by inflammasomes C Ross, AH Chan, JB von Pein, MP Maddugoda, D Boucher, K Schroder Annual review of immunology 40, 249-269, 2022 | 71 | 2022 |
| Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD R Heilig, M Dilucca, D Boucher, KW Chen, D Hancz, B Demarco, ... Life science alliance 3 (6), 2020 | 69 | 2020 |
| Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome C Ross, AH Chan, J Von Pein, D Boucher, K Schroder Life science alliance 1 (6), 2018 | 62 | 2018 |
| Salmonella-induced inflammasome activation in humans D Bierschenk, D Boucher, K Schroder Molecular immunology 86, 38-43, 2017 | 53 | 2017 |
| The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses D Bierschenk, M Monteleone, F Moghaddas, PJ Baker, SL Masters, ... Journal of leukocyte biology 105 (2), 401-410, 2019 | 48 | 2019 |
| Cutting edge: Blockade of inhibitor of apoptosis proteins sensitizes neutrophils to TNF-but not lipopolysaccharide-mediated cell death and IL-1β secretion KW Chen, KE Lawlor, JB Von Pein, D Boucher, M Gerlic, BA Croker, ... The Journal of Immunology 200 (10), 3341-3346, 2018 | 33 | 2018 |
| General in vitro caspase assay procedures D Boucher, C Duclos, JB Denault Caspases, Paracaspases, and Metacaspases: Methods and Protocols, 3-39, 2014 | 24 | 2014 |
| Variation in hemolysin A expression between uropathogenic Escherichia coli isolates determines NLRP3‐dependent vs. ‐independent macrophage cell death … AMV Murthy, MJ Sullivan, NTK Nhu, AW Lo, MD Phan, KM Peters, ... The FASEB Journal 33 (6), 7437-7450, 2019 | 22 | 2019 |
| Molecular determinants involved in activation of caspase 7 D Boucher, V Blais, M Drag, JB Denault Bioscience reports 31 (4), 283-294, 2011 | 21 | 2011 |
| Great balls of fire: activation and signalling of inflammatory caspases G Bateman, B Hill, R Knight, D Boucher Biochemical Society Transactions 49 (3), 1311-1324, 2021 | 20 | 2021 |
| Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme AH Chan, SS Burgener, K Vezyrgiannis, X Wang, J Acklam, JB Von Pein, ... Life Science Alliance 6 (10), 2023 | 11 | 2023 |
| Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network KW Chen, D Boucher, P Broz Cell research 29 (3), 181-182, 2019 | 10 | 2019 |
| Burn the house, save the day: pyroptosis in pathogen restriction D Boucher, KW Chen, K Schroder Inflammasome 2 (1), 1-6, 2015 | 10 | 2015 |
