David Ascher

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Douglas PiresSchool of Computing and Information Systems, The University of MelbourneE-mail confirmado em unimelb.edu.au
Tom L BlundellEmeritus Professor of Biochemistry, University of CambridgeE-mail confirmado em cam.ac.uk
Carlos RodriguesBaker Heart and Diabetes InstituteE-mail confirmado em baker.edu.au
Michael W. ParkerSt Vincent's Institute of Medical Research and The University of MelbourneE-mail confirmado em svi.edu.au
Yoochan MyungUniversity of MelbourneE-mail confirmado em student.unimelb.edu.au
Craig MortonPrincipal Research Scientist, CSIROE-mail confirmado em CSIRO.au
Stephanie PortelliUniversity of MelbourneE-mail confirmado em student.unimelb.edu.au
Lisa KaminskasAssociate Professor of Pharmacology and NHMRC Research Fellow, University of QueenslandE-mail confirmado em monash.edu
Malancha KarmakarUniversität zu KölnE-mail confirmado em uni-koeln.de
Harry JubbCresset Biomolecular Discovery LtdE-mail confirmado em cresset-group.com
Justin DenholmVictorian Tuberculosis ProgramE-mail confirmado em mh.org.au
Dimitri Y. ChirgadzeUniversity of CambridgeE-mail confirmado em cam.ac.uk
Tracy NeroE-mail confirmado em unimelb.edu.au
Arun Prasad PanduranganDepartment of Biochemistry, University of CambridgeE-mail confirmado em cam.ac.uk
Chris PorterDirector, Monash Institute of Pharmaceutical Sciences, Monash UniversityE-mail confirmado em monash.edu
Kathryn HoltMonash University & LSHTME-mail confirmado em lshtm.ac.uk
Taane G. ClarkProfessor of Genomics & Global Health, London School of Hygiene and Tropical MedicineE-mail confirmado em lshtm.ac.uk
Hugh HarrisThe University of AdelaideE-mail confirmado em adelaide.edu.au
Jody PhelanLSHTME-mail confirmado em lshtm.ac.uk
Valerie MizrahiUniversity of Cape TownE-mail confirmado em uct.ac.za

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David Ascher

University of Queensland; Baker Institute; Bio21 Institute

E-mail confirmado em uq.edu.au - Página inicial

Structural Bioinformatics Computational Biology Medical Informatics Machine Learning Drug Discovery


Título Ordenar por citações Ordenar por ano Ordenar por título	Citado por Citado por	Ano
pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures DEV Pires, TL Blundell, DB Ascher Journal of medicinal chemistry 58 (9), 4066-4072, 2015	1407	2015
mCSM: predicting the effects of mutations in proteins using graph-based signatures DEV Pires, DB Ascher, TL Blundell Bioinformatics 30 (3), 335-342, 2014	646	2014
DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach DEV Pires, DB Ascher, TL Blundell Nucleic acids research 42 (W1), W314-W319, 2014	549	2014
DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability CHM Rodrigues, DEV Pires, DB Ascher Nucleic acids research 46 (W1), W350-W355, 2018	477	2018
SDM: a server for predicting effects of mutations on protein stability AP Pandurangan, B Ochoa-Montaño, DB Ascher, TL Blundell Nucleic acids research 45 (W1), W229-W235, 2017	304	2017
Arpeggio: a web server for calculating and visualising interatomic interactions in protein structures HC Jubb, AP Higueruelo, B Ochoa-Montaño, WR Pitt, DB Ascher, ... Journal of molecular biology 429 (3), 365-371, 2017	270	2017
mCSM-PPI2: predicting the effects of mutations on protein–protein interactions CHM Rodrigues, Y Myung, DEV Pires, DB Ascher Nucleic acids research 47 (W1), W338-W344, 2019	151	2019
DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair BL Sibanda, DY Chirgadze, DB Ascher, TL Blundell Science 355 (6324), 520-524, 2017	147	2017
Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam KE Holt, P McAdam, PVK Thai, NTT Thuong, DTM Ha, NN Lan, NH Lan, ... Nature genetics 50 (6), 849-856, 2018	136	2018
Tumour risks and genotype–phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB, SDHC and SDHD KA Andrews, DB Ascher, DEV Pires, DR Barnes, L Vialard, RT Casey, ... Journal of medical genetics 55 (6), 384-394, 2018	134	2018
Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation J Traynelis, M Silk, Q Wang, SF Berkovic, L Liu, DB Ascher, DJ Balding, ... Genome research 27 (10), 1715-1729, 2017	122	2017
Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA DB Ascher, J Wielens, TL Nero, L Doughty, CJ Morton, MW Parker Scientific reports 4 (1), 1-12, 2014	119	2014
Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health HC Jubb, AP Pandurangan, MA Turner, B Ochoa-Montaño, TL Blundell, ... Progress in biophysics and molecular biology 128, 3-13, 2017	118	2017
Flexibility and small pockets at protein–protein interfaces: new insights into druggability H Jubb, TL Blundell, DB Ascher Progress in biophysics and molecular biology 119 (1), 2-9, 2015	109	2015
Identification and characterization of a new cognitive enhancer based on inhibition of insulin‐regulated aminopeptidase AL Albiston, CJ Morton, HL Ng, V Pham, HR Yeatman, S Ye, ... The FASEB Journal 22 (12), 4209-4217, 2008	109	2008
mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance DEV Pires, TL Blundell, DB Ascher Scientific reports 6 (1), 1-8, 2016	105	2016
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance J Phelan, F Coll, R McNerney, DB Ascher, DEV Pires, N Furnham, ... BMC medicine 14 (1), 1-13, 2016	98	2016
Huntingtin inclusions trigger cellular quiescence, deactivate apoptosis, and lead to delayed necrosis YM Ramdzan, MM Trubetskov, AR Ormsby, EA Newcombe, X Sui, ... Cell reports 19 (5), 919-927, 2017	88	2017
CSM-lig: a web server for assessing and comparing protein–small molecule affinities DEV Pires, DB Ascher Nucleic acids research 44 (W1), W557-W561, 2016	88	2016
Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on ‘black bone disease’in Italy M Nemethova, J Radvanszky, L Kadasi, DB Ascher, DEV Pires, ... European Journal of Human Genetics 24 (1), 66-72, 2016	88	2016

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