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Chon Lok Lei
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Calibration of ionic and cellular cardiac electrophysiology models
DG Whittaker, M Clerx, CL Lei, DJ Christini, GR Mirams
Wiley Interdisciplinary Reviews: Systems Biology and Medicine 12 (4), e1482, 2020
932020
A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer
CL Lei, A Fabbri, DG Whittaker, M Clerx, MJ Windley, AP Hill, GR Mirams, ...
Wellcome Open Research 5, 2020
85*2020
Considering discrepancy when calibrating a mechanistic electrophysiology model
CL Lei, S Ghosh, DG Whittaker, Y Aboelkassem, KA Beattie, CD Cantwell, ...
Philosophical Transactions of the Royal Society A 378 (2173), 20190349, 2020
512020
Probabilistic inference on noisy time series (PINTS)
M Clerx, M Robinson, B Lambert, CL Lei, S Ghosh, GR Mirams, ...
arXiv preprint arXiv:1812.07388, 2018
512018
Beta-cell hubs maintain Ca2+ oscillations in human and mouse islet simulations
CL Lei, JA Kellard, M Hara, JD Johnson, B Rodriguez, LJB Briant
Islets 10 (4), 151-167, 2018
492018
Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments
CL Lei, M Clerx, DG Whittaker, DJ Gavaghan, TP de Boer, GR Mirams
Philosophical Transactions of the Royal Society A 378 (2173), 20190348, 2020
472020
Rapid characterization of hERG channel kinetics I: using an automated high-throughput system
CL Lei, M Clerx, DJ Gavaghan, L Polonchuk, GR Mirams, K Wang
Biophysical Journal 117 (12), 2438-2454, 2019
462019
Tailoring mathematical models to stem-cell derived cardiomyocyte lines can improve predictions of drug-induced changes to their electrophysiology
CL Lei, K Wang, M Clerx, RH Johnstone, MP Hortigon-Vinagre, V Zamora, ...
Frontiers in physiology 8, 986, 2017
462017
Rapid characterization of hERG channel kinetics II: temperature dependence
CL Lei, M Clerx, KA Beattie, D Melgari, JC Hancox, DJ Gavaghan, ...
Biophysical Journal 117 (12), 2455-2470, 2019
422019
An audit of uncertainty in multi-scale cardiac electrophysiology models
RH Clayton, Y Aboelkassem, CD Cantwell, C Corrado, T Delhaas, ...
Philosophical Transactions of the Royal Society A 378 (2173), 20190335, 2020
382020
3D printed biomimetic cochleae and machine learning co-modelling provides clinical informatics for cochlear implant patients
IM Lei, C Jiang, CL Lei, SR de Rijk, YC Tam, C Swords, MPF Sutcliffe, ...
Nature Communications 12 (1), 6260, 2021
272021
A hackable, multi-functional, and modular extrusion 3D printer for soft materials
IM Lei, Y Sheng, CL Lei, C Leow, YYS Huang
Scientific Reports 12 (1), 12294, 2022
142022
Autocorrelated measurement processes and inference for ordinary differential equation models of biological systems
B Lambert, CL Lei, M Robinson, M Clerx, R Creswell, S Ghosh, S Tavener, ...
Journal of the Royal Society Interface 20 (199), 20220725, 2023
112023
Neural network differential equations for ion channel modelling
CL Lei, GR Mirams
Frontiers in Physiology 12, 708944, 2021
92021
A Bayesian nonparametric method for detecting rapid changes in disease transmission
R Creswell, M Robinson, D Gavaghan, KV Parag, CL Lei, B Lambert
Journal of Theoretical Biology 558, 111351, 2023
72023
Learning transmission dynamics modelling of COVID-19 using comomodels
SA van der Vegt, L Dai, I Bouros, HJ Farm, R Creswell, O Dimdore-Miles, ...
Mathematical Biosciences 349, 108824, 2022
72022
Using flexible noise models to avoid noise model misspecification in inference of differential equation time series models
R Creswell, B Lambert, CL Lei, M Robinson, D Gavaghan
arXiv preprint arXiv:2011.04854, 2020
72020
Model-driven optimal experimental design for calibrating cardiac electrophysiology models
CL Lei, M Clerx, DJ Gavaghan, GR Mirams
Computer Methods and Programs in Biomedicine 240, 107690, 2023
62023
Calibration of ionic and cellular cardiac electrophysiology models. Wires Syst Biol Med 12 (4): e1482
DG Whittaker, M Clerx, CL Lei, DJ Christini, GR Mirams
52020
Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings
AP Clark, M Clerx, S Wei, CL Lei, TP de Boer, GR Mirams, DJ Christini, ...
Europace 25 (9), euad243, 2023
42023
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