| Global landscape of HIV–human protein complexes S Jaeger, P Cimermancic, N Gulbahce, JR Johnson, KE McGovern, ... Nature 481 (7381), 365-370, 2012 | 781 | 2012 |
| Structure- and function-based design of Plasmodium-selective proteasome inhibitors H Li, AJ O’Donoghue, WA Van Der Linden, SC Xie, E Yoo, IT Foe, L Tilley, ... Nature 530 (7589), 233-236, 2016 | 242 | 2016 |
| Global identification of peptidase specificity by multiplex substrate profiling AJ O'Donoghue, AA Eroy-Reveles, GM Knudsen, J Ingram, M Zhou, ... Nature Methods 9 (11), 1095-1100, 2012 | 181 | 2012 |
| Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase AJ O’Donoghue, Y Jin, GM Knudsen, NC Perera, DE Jenne, JE Murphy, ... PloS one 8 (9), e75141, 2013 | 149 | 2013 |
| IL-1β is an innate immune sensor of microbial proteolysis CN LaRock, J Todd, DL LaRock, J Olson, AJ O’Donoghue, ... Science Immunology 1 (2), eaah3539-eaah3539, 2016 | 141 | 2016 |
| A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding G Wendt, L Zhao, R Chen, C Liu, AJ O’Donoghue, CR Caffrey, ML Reese, ... Science 369 (6511), 1644-1649, 2020 | 124 | 2020 |
| Cloning and characterization of osteoclast precursors from the RAW264. 7 cell line BLV Cuetara, TN Crotti, AJ O'Donoghue, KP Mchugh In Vitro Cellular & Developmental Biology-Animal 42, 182-188, 2006 | 124 | 2006 |
| Skin commensal Malassezia globosa secreted protease attenuates Staphylococcus aureus biofilm formation H Li, BN Goh, WK Teh, Z Jiang, JPZ Goh, A Goh, G Wu, SS Hoon, ... Journal of Investigative Dermatology 138 (5), 1137-1145, 2018 | 118 | 2018 |
| Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles O Julien, M Zhuang, AP Wiita, AJ O’Donoghue, GM Knudsen, CS Craik, ... Proceedings of the National Academy of Sciences 113 (14), E2001-E2010, 2016 | 112 | 2016 |
| Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders V Hook, M Yoon, C Mosier, G Ito, S Podvin, BP Head, R Rissman, ... Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1868 (8), 140428, 2020 | 101 | 2020 |
| A parasite cysteine protease is key to host protein degradation and iron acquisition∗ TC O'Brien, ZB Mackey, RD Fetter, Y Choe, AJ O'Donoghue, M Zhou, ... Journal of Biological Chemistry 283 (43), 28934-28943, 2008 | 100 | 2008 |
| A clinical-stage cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells DM Mellott, CT Tseng, A Drelich, P Fajtová, BC Chenna, DH Kostomiris, ... ACS chemical biology 16 (4), 642-650, 2021 | 93 | 2021 |
| Immunoproteasome functions explained by divergence in cleavage specificity and regulation MB Winter, F La Greca, S Arastu-Kapur, F Caiazza, P Cimermancic, ... Elife 6, e27364, 2017 | 84 | 2017 |
| Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome AJ O’Donoghue, GM Knudsen, C Beekman, JA Perry, AD Johnson, ... Proceedings of the National Academy of Sciences 112 (24), 7478-7483, 2015 | 84 | 2015 |
| Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity GM LaMonte, J Almaliti, B Bibo-Verdugo, L Keller, BY Zou, J Yang, ... Journal of medicinal chemistry 60 (15), 6721-6732, 2017 | 80 | 2017 |
| A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells M Mahoney, VC Damalanka, MA Tartell, DH Chung, AL Lourenço, ... Proceedings of the National Academy of Sciences 118 (43), e2108728118, 2021 | 71 | 2021 |
| Neutrophilic proteolysis in the cystic fibrosis lung correlates with a pathogenic microbiome RA Quinn, S Adem, RH Mills, W Comstock, L DeRight Goldasich, ... Microbiome 7, 1-13, 2019 | 62 | 2019 |
| Targeting proteasomes in infectious organisms to combat disease B Bibo‐Verdugo, Z Jiang, CR Caffrey, AJ O'Donoghue The FEBS journal 284 (10), 1503-1517, 2017 | 61 | 2017 |
| A charge‐switchable zwitterionic peptide for rapid detection of SARS‐CoV‐2 main protease Z Jin, Y Mantri, M Retout, Y Cheng, J Zhou, A Jorns, P Fajtova, W Yim, ... Angewandte Chemie 134 (9), e202112995, 2022 | 57 | 2022 |
| Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis JL Small, AJ O'Donoghue, EC Boritsch, OV Tsodikov, GM Knudsen, ... Journal of Biological Chemistry 288 (18), 12489-12499, 2013 | 52 | 2013 |
Charles CraikProfessor of Pharmaceutical Chemistry, UCSFE-mail confirmado em ucsf.edu
