Timothy R. Rudd
Timothy R. Rudd
National Institute for Biological Standards and Control (NIBSC)
E-mail confirmado em nibsc.org
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Heparan sulfate and heparin interactions with proteins
MCZ Meneghetti, AJ Hughes, TR Rudd, HB Nader, AK Powell, EA Yates, ...
Journal of the Royal Society Interface 12 (110), 20150589, 2015
1382015
N-glycosylation of fibroblast growth factor receptor 1 regulates ligand and heparan sulfate co-receptor binding
L Duchesne, B Tissot, TR Rudd, A Dell, DG Fernig
Journal of Biological Chemistry 281 (37), 27178-27189, 2006
1062006
Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives
TR Rudd, SE Guimond, MA Skidmore, L Duchesne, M Guerrini, G Torri, ...
Glycobiology 17 (9), 983-993, 2007
832007
Real-time monitoring of the development and stability of biofilms of Streptococcus mutans using the quartz crystal microbalance with dissipation monitoring
AL Schofield, TR Rudd, DS Martin, DG Fernig, C Edwards
Biosensors and Bioelectronics 23 (3), 407-413, 2007
752007
Diversification of the structural determinants of fibroblast growth factor-heparin interactions implications for binding specificity
R Xu, A Ori, TR Rudd, KA Uniewicz, YA Ahmed, SE Guimond, ...
Journal of Biological Chemistry 287 (47), 40061-40073, 2012
702012
Glycosaminoglycan origin and structure revealed by multivariate analysis of NMR and CD spectra
TR Rudd, MA Skidmore, SE Guimond, C Cosentino, G Torri, DG Fernig, ...
Glycobiology 19 (1), 52-67, 2009
562009
The conformation and structure of GAGs: recent progress and perspectives
TR Rudd, MA Skidmore, M Guerrini, M Hricovini, AK Powell, G Siligardi, ...
Current opinion in structural biology 20 (5), 567-574, 2010
512010
An unusual antithrombin-binding heparin octasaccharide with an additional 3-O-sulfated glucosamine in the active pentasaccharide sequence
M Guerrini, S Elli, P Mourier, TR Rudd, D Gaudesi, B Casu, C Boudier, ...
Biochemical Journal 449 (2), 343-351, 2013
502013
Site-specific interactions of copper (II) ions with heparin revealed with complementary (SRCD, NMR, FTIR and EPR) spectroscopic techniques
TR Rudd, MA Skidmore, SE Guimond, M Guerrini, C Cosentino, R Edge, ...
Carbohydrate research 343 (12), 2184-2193, 2008
462008
CDApps: integrated software for experimental planning and data processing at beamline B23, Diamond Light Source
R Hussain, K Benning, T Javorfi, E Longo, TR Rudd, B Pulford, G Siligardi
Journal of synchrotron radiation 22 (2), 465-468, 2015
452015
Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships
TR Rudd, KA Uniewicz, A Ori, SE Guimond, MA Skidmore, D Gaudesi, ...
Organic & biomolecular chemistry 8 (23), 5390-5397, 2010
452010
The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation
MA Skidmore, SE Guimond, TR Rudd, DG Fernig, JE Turnbull, EA Yates
Connective tissue research 49 (3-4), 140-144, 2008
402008
Analysis of the fibroblast growth factor receptor (FGFR) signalling network with heparin as coreceptor: evidence for the expansion of the core FGFR signalling network
R Xu, TR Rudd, AJ Hughes, G Siligardi, DG Fernig, EA Yates
The FEBS journal 280 (10), 2260-2270, 2013
372013
Protein–GAG interactions: new surface-based techniques, spectroscopies and nanotechnology probes
EA Yates, CJ Terry, C Rees, TR Rudd, L Duchesne, MA Skidmore, R Levy, ...
Biochemical Society Transactions 34 (3), 427-430, 2006
372006
A highly efficient tree structure for the biosynthesis of heparan sulfate accounts for the commonly observed disaccharides and suggests a mechanism for domain synthesis
TR Rudd, EA Yates
Molecular BioSystems 8 (5), 1499-1506, 2012
362012
Human (α2→ 6) and avian (α2→ 3) sialylated receptors of influenza A virus show distinct conformations and dynamics in solution
GL Sassaki, S Elli, TR Rudd, E Macchi, EA Yates, A Naggi, Z Shriver, ...
Biochemistry 52 (41), 7217-7230, 2013
352013
A new approach for heparin standardization: Combination of scanning UV spectroscopy, nuclear magnetic resonance and principal component analysis
MA Lima, TR Rudd, EHC de Farias, LF Ebner, TF Gesteira, LM de Souza, ...
PLoS One 6 (1), e15970, 2011
352011
Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin.
C Mycroft-West, D Su, I Pagani, T Rudd, S Elli, S Guimond, G Miller, ...
bioRxiv, 2020
332020
Differentiation of generic enoxaparins marketed in the United States by employing NMR and multivariate analysis
M Guerrini, TR Rudd, L Mauri, E Macchi, J Fareed, EA Yates, A Naggi, ...
Analytical chemistry 87 (16), 8275-8283, 2015
332015
New applications of heparin and other glycosaminoglycans
M Lima, T Rudd, E Yates
Molecules 22 (5), 749, 2017
322017
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