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Arthur Eugen Kummerle
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The methylation effect in medicinal chemistry
EJ Barreiro, AE Kümmerle, CAM Fraga
Chemical reviews 111 (9), 5215-5246, 2011
7772011
Coumarin compounds in medicinal chemistry: some important examples from the last years
TM Pereira, DP Franco, F Vitorio, AE Kummerle
Current topics in medicinal chemistry 18 (2), 124-148, 2018
1722018
Multicomponent reactions for the synthesis of bioactive compounds: A review
CS Graebin, FV Ribeiro, KR Rogério, AE Kümmerle
Current Organic Synthesis 16 (6), 855-899, 2019
1542019
Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues
AG Silva, G Zapata-Sudo, AE Kummerle, CAM Fraga, EJ Barreiro, ...
Bioorganic & medicinal chemistry 13 (10), 3431-3437, 2005
1392005
Design, Synthesis, and Pharmacological Evaluation of N-Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally …
AE Kümmerle, M Schmitt, SVS Cardozo, C Lugnier, P Villa, AB Lopes, ...
Journal of medicinal chemistry 55 (17), 7525-7545, 2012
1142012
Characterization of Amide Bond Conformers for a Novel Heterocyclic Template of N-acylhydrazone Derivatives
AB Lopes, E Miguez, AE Kümmerle, VM Rumjanek, CAM Fraga, ...
Molecules 18 (10), 11683-11704, 2013
1102013
Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives
AE Kümmerle, JM Raimundo, CM Leal, GS da Silva, TL Balliano, ...
European journal of medicinal chemistry 44 (10), 4004-4009, 2009
1022009
Design, synthesis and analgesic properties of novel conformationally-restricted N-acylhydrazones (NAH)
AE Kümmerle, MM Vieira, M Schmitt, ALP Miranda, CAM Fraga, ...
Bioorganic & medicinal chemistry letters 19 (17), 4963-4966, 2009
562009
Synthesis and mechanism of novel fluorescent coumarin–dihydropyrimidinone dyads obtained by the Biginelli multicomponent reaction
F Vitório, TM Pereira, RN Castro, GP Guedes, CS Graebin, AE Kümmerle
New Journal of Chemistry 39 (3), 2323-2332, 2015
542015
Beneficial effects of a novel agonist of the adenosine A2A receptor on monocrotaline‐induced pulmonary hypertension in rats
AKN Alencar, SL Pereira, TL Montagnoli, RC Maia, AE Kümmerle, ...
British journal of pharmacology 169 (5), 953-962, 2013
522013
Antihypertensive profile of 2-thienyl-3, 4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor
CM Leal, SL Pereira, AE Kümmerle, DM Leal, R Tesch, ...
European journal of medicinal chemistry 55, 49-57, 2012
512012
Microwave-assisted synthesis and photophysical studies of novel fluorescent N-acylhydrazone and semicarbazone-7-OH-coumarin dyes
TM Pereira, F Vitório, RC Amaral, KPS Zanoni, NYM Iha, AE Kümmerle
New Journal of Chemistry 40 (10), 8846-8854, 2016
402016
LASSBio-294, a compound with inotropic and lusitropic activity, decreases cardiac remodeling and improves Ca2+ influx into sarcoplasmic reticulum after myocardial infarction
DG Costa, JS Da Silva, AE Kümmerle, RT Sudo, SS Landgraf, ...
American journal of hypertension 23 (11), 1220-1227, 2010
332010
Novel thienylacylhydrazone derivatives inhibit platelet aggregation through cyclic nucleotides modulation and thromboxane A2 synthesis inhibition
FCF Brito, AE Kummerle, C Lugnier, CAM Fraga, EJ Barreiro, ...
European journal of pharmacology 638 (1-3), 5-12, 2010
312010
Reações Multicomponentes: Um breve Histórico e a Versatilidade destas Reações na Síntese de Moléculas Bioativas
K Rogerio, F Vitório, A Kümmerle, C Graebin
Rev. Virtual Quim 8, 1934-1962, 2016
302016
MAOS and medicinal chemistry: Some important examples from the last years
NM Nascimento-Júnior, AE Kümmerle, EJ Barreiro, CAM Fraga
Molecules 16 (11), 9274-9297, 2011
282011
Discovery of novel dual-active 3-(4-(dimethylamino) phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant
GA de Souza, SJ da Silva, CN Del Cistia, P Pitasse-Santos, LO Pires, ...
Journal of Enzyme Inhibition and Medicinal Chemistry 34 (1), 631-637, 2019
242019
Recent progress in methylation of (hetero) arenes by cross-coupling or C–H activation
L Hu, YA Liu, X Liao
Synlett 29 (04), 375-382, 2018
242018
Pharmacological characterization of (3-thienylidene)-3, 4-methylenedioxybenzoylhydrazide: A novel muscarinic agonist with antihypertensive profile
G Zapata-Sudo, SL Pereira, HJV Beiral, AE Kummerle, JM Raimundo, ...
American journal of hypertension 23 (2), 135-141, 2010
242010
O uso de aparelhos de micro-ondas domésticos em aulas experimentais de química orgânica: nitração de salicilaldeído
EF Teixeira, APB Santos, RS Bastos, AC Pinto, AE Kümmerle, RR Coelho
Química Nova 33, 1603-1606, 2010
242010
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