Emmanouil Metzakopian
Emmanouil Metzakopian
UK Dementia Research Institute_Cambridge University
E-mail confirmado em cam.ac.uk - Página inicial
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A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia
K Tzelepis, H Koike-Yusa, E De Braekeleer, Y Li, E Metzakopian, ...
Cell reports 17 (4), 1193-1205, 2016
3652016
Predicting the mutations generated by repair of Cas9-induced double-strand breaks
F Allen, L Crepaldi, C Alsinet, AJ Strong, V Kleshchevnikov, P De Angeli, ...
Nature biotechnology 37 (1), 64-72, 2019
2332019
Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development
W Lin, E Metzakopian, YE Mavromatakis, N Gao, N Balaskas, H Sasaki, ...
Developmental biology 333 (2), 386-396, 2009
1602009
Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages
SRW Stott, E Metzakopian, W Lin, KH Kaestner, R Hen, SL Ang
Journal of Neuroscience 33 (18), 8022-8034, 2013
802013
UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs
M Gozdecka, E Meduri, M Mazan, K Tzelepis, M Dudek, AJ Knights, ...
Nature genetics 50 (6), 883-894, 2018
752018
ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
G Balmus, D Pilger, J Coates, M Demir, M Sczaniecka-Clift, AC Barros, ...
Nature communications 10 (1), 1-18, 2019
742019
A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer
R Rad, L Rad, W Wang, A Strong, H Ponstingl, IF Bronner, M Mayho, ...
Nature genetics 47 (1), 47-56, 2015
702015
Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity
YE Mavromatakis, W Lin, E Metzakopian, ALM Ferri, CH Yan, H Sasaki, ...
Mechanisms of development 128 (1-2), 90-103, 2011
662011
Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors
E Metzakopian, W Lin, M Salmon-Divon, H Dvinge, E Andersson, ...
Development 139 (14), 2625-2634, 2012
552012
Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
FH Siddiqi, FM Menzies, A Lopez, E Stamatakou, C Karabiyik, R Ureshino, ...
Nature communications 10 (1), 1-14, 2019
452019
A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes
J De La Rosa, J Weber, MJ Friedrich, Y Li, L Rad, H Ponstingl, Q Liang, ...
Nature genetics 49 (5), 730-741, 2017
332017
Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries
E Metzakopian, A Strong, V Iyer, A Hodgkins, K Tzelepis, L Antunes, ...
Scientific reports 7 (1), 1-9, 2017
312017
Genome-scale CRISPRa screen identifies novel factors for cellular reprogramming
J Yang, SS Rajan, MJ Friedrich, G Lan, X Zou, H Ponstingl, DA Garyfallos, ...
Stem cell reports 12 (4), 757-771, 2019
302019
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4
K Tzelepis, E De Braekeleer, D Aspris, I Barbieri, MS Vijayabaskar, ...
Nature communications 9 (1), 1-13, 2018
272018
Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells
E Metzakopian, K Bouhali, M Alvarez-Saavedra, JA Whitsett, DJ Picketts, ...
Development 142 (7), 1315-1324, 2015
212015
Dynamics of indel profiles induced by various CRISPR/Cas9 delivery methods
M Kosicki, SS Rajan, FC Lorenzetti, HH Wandall, Y Narimatsu, ...
Progress in molecular biology and translational science 152, 49-67, 2017
202017
Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation
A Chabrat, G Brisson, H Doucet-Beaupré, C Salesse, MS Profes, ...
Nature communications 8 (1), 1-15, 2017
182017
Single-cell transcriptomics of Parkinson’s disease human in vitro models reveals dopamine neuron-specific stress responses
HJR Fernandes, N Patikas, S Foskolou, SF Field, JE Park, ML Byrne, ...
Cell Reports 33 (2), 108263, 2020
142020
A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia. Cell Rep 17: 1193–1205
K Tzelepis, H Koike-Yusa, E De Braekeleer, Y Li, E Metzakopian, ...
112016
ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanisms
EL Wilson, E Metzakopian
Cell Death & Differentiation 28 (6), 1804-1821, 2021
102021
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