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Melissa Nelson
Melissa Nelson
On Target Laboratories, Inc.
E-mail confirmado em ontargetlabs.com
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Folate–vinca alkaloid conjugates for cancer therapy: A structure–activity relationship
CP Leamon, IR Vlahov, JA Reddy, M Vetzel, HKR Santhapuram, F You, ...
Bioconjugate chemistry 25 (3), 560-568, 2014
822014
Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications
CP Leamon, JA Reddy, PJ Klein, IR Vlahov, R Dorton, A Bloomfield, ...
Journal of Pharmacology and Experimental Therapeutics 336 (2), 336-343, 2011
632011
Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic
JA Reddy, R Dorton, A Bloomfield, M Nelson, C Dircksen, M Vetzel, ...
Scientific reports 8 (1), 8943, 2018
542018
Preclinical evaluation of bispecific adaptor molecule controlled folate receptor CAR-T cell therapy with special focus on pediatric malignancies
YJ Lu, H Chu, LW Wheeler, M Nelson, E Westrick, JF Matthaei, II Cardle, ...
Frontiers in oncology 9, 151, 2019
512019
Conjugates for treating diseases caused by PSMA expressing cells
IR Vlahov, JA Reddy, A Bloomfield, R Dorton, M Nelson, M Vetzel, ...
US Patent 9,636,413, 2017
342017
Rational combination therapy of vintafolide (EC145) with commonly used chemotherapeutic drugs
JA Reddy, R Dorton, A Bloomfield, M Nelson, M Vetzel, J Guan, ...
Clinical Cancer Research 20 (8), 2104-2114, 2014
322014
Conjugates for treating diseases caused by PSMA expressing cells
IR Vlahov, JA Reddy, A Bloomfield, R Dorton, M Nelson, M Vetzel, ...
US Patent 9,782,493, 2017
282017
Conjugates for treating diseases caused by psma expressing cells
IR Vlahov, JA Reddy, A Bloomfield, R Dorton, M Nelson, M Vetzel, ...
US Patent App. 15/245,508, 2016
272016
Conjugates for treating diseases caused by psma expressing cells
IR Vlahov, JA Reddy, A Bloomfield, R Dorton, M Nelson, M Vetzel, ...
US Patent App. 15/245,512, 2016
272016
Prostate-specific membrane antigen-specific antitumor activity of a self-immolative tubulysin conjugate
CP Leamon, JA Reddy, A Bloomfield, R Dorton, M Nelson, M Vetzel, ...
Bioconjugate Chemistry 30 (6), 1805-1813, 2019
262019
Latent warheads for targeted cancer therapy: Design and synthesis of pro-pyrrolobenzodiazepines and conjugates
IR Vlahov, L Qi, PJ Kleindl, HK Santhapuram, A Felten, GL Parham, ...
Bioconjugate Chemistry 28 (12), 2921-2931, 2017
182017
High levels of expression of P-glycoprotein/multidrug resistance protein result in resistance to vintafolide
AD Guertin, J O'Neil, A Stoeck, JA Reddy, R Cristescu, BB Haines, ...
Molecular Cancer Therapeutics 15 (8), 1998-2008, 2016
142016
Pre-clinical development of EC1456: a potent folate targeted tubulysin SMDC
JA Reddy, A Bloomfield, M Nelson, R Dorton, M Vetzel, CP Leamon
Cancer research 74 (19_Supplement), 832-832, 2014
142014
PSMA-specific anti-tumor activity of the targeted-tubulysin conjugate, EC1169.
JA Reddy, A Bloomfield, R Dorton, M Nelson, M Vetzel, S Hahn, I Vlahov, ...
Cancer research 73 (8_Supplement), 2145-2145, 2013
92013
Pre-clinical studies of EC2629, a highly potent folate-receptor-targeted DNA crosslinking agent
JA Reddy, M Nelson, C Dircksen, M Vetzel, T Johnson, V Cross, ...
Scientific reports 10 (1), 12772, 2020
82020
Detecting functional and accessible folate receptor expression in cancer and polycystic kidneys
H Chu, JM Shillingford, JA Reddy, E Westrick, M Nelson, EZ Wang, ...
Molecular Pharmaceutics 16 (9), 3985-3995, 2019
72019
Methods of treating cancer with tubulysin conjugates
CP Leamon, JA Reddy, B Nguyen, A Bloomfield, M Nelson, R Dorton
US Patent App. 15/514,193, 2017
62017
Preclinical evaluation of bispecific adaptor molecule controlled folate receptor CAR-T cell therapy with special focus on pediatric malignancies. Front Oncol. 2019; 9: 151
YJ Lu, H Chu, LW Wheeler, M Nelson, E Westrick, JF Matthaei, II Cardle, ...
Go to original source... Go to PubMed, 2019
52019
Openness to experience and working alliance: A preliminary report
ML Nelson, CS Taylor
annual meeting of the American Psychological Association, Toronto, 1993
51993
Development and validation of a UPLC–MS/MS method for the novel folate-targeted small molecule drug conjugate EC1456 and its metabolites in tumor homogenates from mice
SI Rao, M Pugh, M Nelson, JA Reddy, PJ Klein, CP Leamon
Journal of Pharmaceutical and Biomedical Analysis 122, 148-156, 2016
42016
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