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Robin Mathew, Ph.D.
Robin Mathew, Ph.D.
Therapeutic Area Strategy Lead, Global Clinical Development
E-mail confirmado em umdnj.edu
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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
K Degenhardt, R Mathew, B Beaudoin, K Bray, D Anderson, G Chen, ...
Cancer cell 10 (1), 51-64, 2006
21902006
Role of autophagy in cancer
R Mathew, V Karantza-Wadsworth, E White
Nature Reviews Cancer 7 (12), 961-967, 2007
19882007
Autophagy suppresses tumorigenesis through elimination of p62
R Mathew, CM Karp, B Beaudoin, N Vuong, G Chen, HY Chen, K Bray, ...
Cell 137 (6), 1062-1075, 2009
17762009
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
JY Guo, HY Chen, R Mathew, J Fan, AM Strohecker, G Karsli-Uzunbas, ...
Genes & development 25 (5), 460-470, 2011
12492011
Autophagy suppresses tumor progression by limiting chromosomal instability
R Mathew, S Kongara, B Beaudoin, CM Karp, K Bray, K Degenhardt, ...
Genes & development 21 (11), 1367-1381, 2007
10252007
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
V Karantza-Wadsworth, S Patel, O Kravchuk, G Chen, R Mathew, S Jin, ...
Genes & development 21 (13), 1621-1635, 2007
9152007
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
JJ Kamphorst, JR Cross, J Fan, E De Stanchina, R Mathew, EP White, ...
Proceedings of the National Academy of Sciences 110 (22), 8882-8887, 2013
5512013
Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
JY Guo, G Karsli-Uzunbas, R Mathew, SC Aisner, JJ Kamphorst, ...
Genes & development 27 (13), 1447-1461, 2013
5232013
Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E–driven lung tumors
AM Strohecker, JY Guo, G Karsli-Uzunbas, SM Price, GJ Chen, R Mathew, ...
Cancer discovery 3 (11), 1272-1285, 2013
3862013
Glutamine‐driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia
J Fan, JJ Kamphorst, R Mathew, MK Chung, E White, T Shlomi, ...
Molecular systems biology 9 (1), 712, 2013
3462013
Role of autophagy in suppression of inflammation and cancer
E White, C Karp, AM Strohecker, Y Guo, R Mathew
Current opinion in cell biology 22 (2), 212-217, 2010
3232010
Metabolic catastrophe as a means to cancer cell death
S Jin, RS DiPaola, R Mathew, E White
Journal of cell science 120 (3), 379-383, 2007
2782007
Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night
R Mathew, E White
Current opinion in genetics & development 21 (1), 113-119, 2011
2612011
NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition
T Shimazu, K Degenhardt, A Nur-E-Kamal, J Zhang, T Yoshida, Y Zhang, ...
Genes & development 21 (8), 929-941, 2007
1572007
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
K Bray, R Mathew, A Lau, JJ Kamphorst, J Fan, J Chen, HY Chen, ...
PloS one 7 (7), e41831, 2012
1392012
Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression
CM Karp, TT Tan, R Mathew, D Nelson, C Mukherjee, K Degenhardt, ...
Cancer research 68 (11), 4105-4115, 2008
1312008
Autophagy, stress, and cancer metabolism: what doesn't kill you makes you stronger
R Mathew, E White
Cold Spring Harbor symposia on quantitative biology 76, 389-396, 2011
1232011
Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity
R Mathew, S Khor, SR Hackett, JD Rabinowitz, DH Perlman, E White
Molecular cell 55 (6), 916-930, 2014
1092014
Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy
RS DiPaola, D Dvorzhinski, A Thalasila, V Garikapaty, D Doram, M May, ...
The Prostate 68 (16), 1743-1752, 2008
1092008
Stromelysin-2 overexpression in human esophageal squamous cell carcinoma: potential clinical implications
R Mathew, R Khanna, R Kumar, M Mathur, NK Shukla, R Ralhan
Cancer detection and prevention 26 (3), 222-228, 2002
732002
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Artigos 1–20