Alan H Fairlamb
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Genome sequence of the human malaria parasite Plasmodium falciparum
MJ Gardner, N Hall, E Fung, O White, M Berriman, RW Hyman, JM Carlton, ...
Nature 419 (6906), 498-511, 2002
Drug resistance in leishmaniasis
SL Croft, S Sundar, AH Fairlamb
Clinical microbiology reviews 19 (1), 111-126, 2006
The Genome of the African Trypanosome Trypanosoma brucei
M Berriman, E Ghedin, C Hertz-Fowler, G Blandin, H Renauld, ...
science 309 (5733), 416-422, 2005
Metabolism and functions of trypanothione in the Kinetoplastida
AH Fairlamb, A Cerami
Annual review of microbiology 46 (1), 695-729, 1992
Trypanothione: a novel bis (glutathionyl) spermidine cofactor for glutathione reductase in trypanosomatids
AH Fairlamb, P Blackburn, P Ulrich, BT Chait, A Cerami
Science 227 (4693), 1485-1487, 1985
Kinetoplastids: related protozoan pathogens, different diseases
K Stuart, R Brun, S Croft, A Fairlamb, RE Gürtler, J McKerrow, S Reed, ...
The Journal of clinical investigation 118 (4), 1301-1310, 2008
Chemotherapy of human African trypanosomiasis: current and future prospects
AH Fairlamb
Trends in parasitology 19 (11), 488-494, 2003
Arsenical-resistant trypanosomes lack an unusual adenosine transporter
NS Carter, AH Fairlamb
Nature 361 (6408), 173-176, 1993
Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress
S Krieger, W Schwarz, MR Ariyanayagam, AH Fairlamb, ...
Molecular microbiology 35 (3), 542-552, 2000
A novel multiple-stage antimalarial agent that inhibits protein synthesis
B Baragaña, I Hallyburton, MCS Lee, NR Norcross, R Grimaldi, TD Otto, ...
Nature 522 (7556), 315-320, 2015
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
MC Field, D Horn, AH Fairlamb, MAJ Ferguson, DW Gray, KD Read, ...
Nature Reviews Microbiology 15 (4), 217-231, 2017
Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani
S Wyllie, ML Cunningham, AH Fairlamb
Journal of Biological Chemistry 279 (38), 39925-39932, 2004
Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages
C Dumas, M Ouellette, J Tovar, ML Cunningham, AH Fairlamb, S Tamar, ...
The EMBO journal, 1997
Purification and characterization of trypanothione reductase from Crithidia fasciculata, a new member of the family of disulfide-containing flavoprotein reductases
SL Shames, AH Fairlamb, A Cerami, CT Walsh
Biochemistry 25 (12), 3519-3526, 1986
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness
JA Frearson, S Brand, SP McElroy, LAT Cleghorn, O Smid, L Stojanovski, ...
Nature 464 (7289), 728-732, 2010
Trypanothione is the primary target for arsenical drugs against African trypanosomes.
AH Fairlamb, GB Henderson, A Cerami
Proceedings of the National Academy of Sciences 86 (8), 2607-2611, 1989
Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells
J Aliberti, JG Valenzuela, VB Carruthers, S Hieny, J Andersen, H Charest, ...
Nature immunology 4 (5), 485-490, 2003
Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen-sensitive and-resistant Trypanosoma brucei brucei
NS Carter, BJ Berger, AH Fairlamb
Journal of Biological Chemistry 270 (47), 28153-28157, 1995
Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors
CS Bond, Y Zhang, M Berriman, ML Cunningham, AH Fairlamb, ...
Structure 7 (1), 81-89, 1999
" Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease.
GB Henderson, P Ulrich, AH Fairlamb, I Rosenberg, M Pereira, M Sela, ...
Proceedings of the National Academy of Sciences 85 (15), 5374-5378, 1988
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